Title:
CELL COMPETITION INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2020/196926
Kind Code:
A1
Abstract:
The present invention provides a cell competition inhibitor comprising an agonist antibody, which is directed against a protein containing the α3 domain of MHC class Ia or LILRB3, or a substance which inhibits the binding of LILRB3 to MHC class Ia.
Inventors:
MARUYAMA TAKESHI (JP)
Application Number:
PCT/JP2020/014715
Publication Date:
October 01, 2020
Filing Date:
March 30, 2020
Export Citation:
Assignee:
UNIV WASEDA (JP)
International Classes:
A61K45/00; A61K38/16; A61K38/17; A61L27/38; A61P21/02; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P31/12; A61P35/00; A61P37/06; A61P43/00; C07K14/705; C12N5/071; C12N5/077; C12N5/078; C12N5/0781; C12N5/0783; C12N5/0786; C12N15/09; C12N15/12
Domestic Patent References:
| WO2018119425A2 | 2018-06-28 | |||
| WO2019144052A1 | 2019-07-25 | |||
| WO2003091424A1 | 2003-11-06 | |||
| WO2005056602A1 | 2005-06-23 |
Foreign References:
| JP2013517330A | 2013-05-16 | |||
| JP2018510340A | 2018-04-12 | |||
| JP2019063594A | 2019-04-25 | |||
| JP2019069777A | 2019-05-09 |
Other References:
SURYAPRAKASH R. SAMBHARA AND RICHARD G. MILLER: "Programmed Cell Deth of T Cells Signaled by the T Cell Reseptor and the a3 Domain of Class I MHC", SCIENCE , vol. 252, 5011, 7 June 1991 (1991-06-07), pages 1424 - 1427, XP002035439, DOI: 10.1126/science.1828618
PFISTERSHAMMER, K. ET AL.: "Allogeneic disparities in immunoglobulin-like transcript 5 induce potent antibody responses in hematopoietic stem cell transplant recipients", BLOOD, vol. 114, no. 11, 2009, pages 2323 - 2332, XP002698075, DOI: 10.1182/blood-2008-10-183814
MORATA, G. ET AL., DEV. BIOL., vol. 42, 1975, pages 211 - 221
HOGAN, C. ET AL., NAT CELL BIOL., vol. 11, no. 4, 2009, pages 460 - 7
MARUYAMA T. ET AL., CURR OPIN CELL BIOL., vol. 48, 2017, pages 106 - 112
MIHOKO KAJITA ET AL., PHARMACOLOGICAL, vol. 140, 2012, pages 76 - 80
VANHOOK M. A., SCI. SIGNAL., vol. 10, pages 478
KARLIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873 - 5877
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
NEEDLEMAN ET AL., J. MOL. BIOL., vol. 48, 1970, pages 444 - 453
MYERSMILLER, CABIOS, vol. 4, 1988, pages 11 - 17
PEARSON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 2444 - 2448
TUERK, C.GOLD, L., SCIENCE, vol. 249, 1990, pages 505 - 510
ELBASHIR ET AL., GENES DEV., vol. 15, 2001, pages 188 - 200
MARUYAMA ET AL., NAT. BIOTECHNOL., 2015
See also references of EP 3949993A4
PFISTERSHAMMER, K. ET AL.: "Allogeneic disparities in immunoglobulin-like transcript 5 induce potent antibody responses in hematopoietic stem cell transplant recipients", BLOOD, vol. 114, no. 11, 2009, pages 2323 - 2332, XP002698075, DOI: 10.1182/blood-2008-10-183814
MORATA, G. ET AL., DEV. BIOL., vol. 42, 1975, pages 211 - 221
HOGAN, C. ET AL., NAT CELL BIOL., vol. 11, no. 4, 2009, pages 460 - 7
MARUYAMA T. ET AL., CURR OPIN CELL BIOL., vol. 48, 2017, pages 106 - 112
MIHOKO KAJITA ET AL., PHARMACOLOGICAL, vol. 140, 2012, pages 76 - 80
VANHOOK M. A., SCI. SIGNAL., vol. 10, pages 478
KARLIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873 - 5877
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
NEEDLEMAN ET AL., J. MOL. BIOL., vol. 48, 1970, pages 444 - 453
MYERSMILLER, CABIOS, vol. 4, 1988, pages 11 - 17
PEARSON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 2444 - 2448
TUERK, C.GOLD, L., SCIENCE, vol. 249, 1990, pages 505 - 510
ELBASHIR ET AL., GENES DEV., vol. 15, 2001, pages 188 - 200
MARUYAMA ET AL., NAT. BIOTECHNOL., 2015
See also references of EP 3949993A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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