Title:
CELL FATE CONVERSION OF DIFFERENTIATED SOMATIC CELLS INTO GLIAL CELLS
Document Type and Number:
WIPO Patent Application WO/2012/058243
Kind Code:
A3
Abstract:
The present invention relates to the reprogramming of differentiated somatic cells, such as those differentiated cells that arise from embryonic mesoderm, into glial cells. Glial cells produced from this reprogramming are functionally equivalent to glial cells that arise from ectodermal origins.
Inventors:
TESAR PAUL J (US)
MILLER ROBERT H (US)
NAJM FADI J (US)
MILLER ROBERT H (US)
NAJM FADI J (US)
Application Number:
PCT/US2011/057762
Publication Date:
August 02, 2012
Filing Date:
October 25, 2011
Export Citation:
Assignee:
UNIV CASE WESTERN RESERVE (US)
TESAR PAUL J (US)
MILLER ROBERT H (US)
NAJM FADI J (US)
TESAR PAUL J (US)
MILLER ROBERT H (US)
NAJM FADI J (US)
International Classes:
C12N5/079; C12N5/10; C12N15/85
Foreign References:
| US7041507B1 | 2006-05-09 | |||
| US20030059939A1 | 2003-03-27 |
Other References:
ZHANG ET AL.: "Increased myelinating capacity of embryonic stem cell derived oligodendrocyte precursors after treatment by interleukin-6/ soluble interleukin-6 receptor fusion protein", MOLECULAR AND CELLULAR NEUROSCIENCE, vol. 31, 1 December 2005 (2005-12-01), pages 387 - 398, XP024908207
VIERBUCHEN ET AL.: "Direct conversion of fibroblasts to functional neurons by defined factors", NATURE, vol. 463, 25 February 2010 (2010-02-25), pages 1035 - 1041, XP055023150
VIERBUCHEN ET AL.: "Direct conversion of fibroblasts to functional neurons by defined factors", NATURE, vol. 463, 25 February 2010 (2010-02-25), pages 1035 - 1041, XP055023150
Attorney, Agent or Firm:
BRASHEARS, Sarah, J. (475 N. Whisman Road Suite 40, Mountain View CA, US)
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