Title:
CELL-FREE METHYLATED AND UNMETHYLATED DNA IN DISEASES RESULTING FROM ABNORMALITIES IN BLOOD GLUCOSE LEVELS
Document Type and Number:
WIPO Patent Application WO/2017/015497
Kind Code:
A3
Abstract:
Disclosed herein are compositions and methods for determining new-onset type 1 diabetes, methylation-specific polymerase chain reaction assays for determining new-onset type 1 diabetes, methods for distinguishing between type 1 diabetes and type 2 diabetes, methods for dysglycemia in obese adolescent subjects including obese adolescent subjects having type 2 diabetes and methylation-specific polymerase chain reaction assays for determining dysglycemia in obese adolescent subjects including obese adolescent subjects having type 2 diabetes.
Inventors:
MIRMIRA RAGHAVENDRA G (US)
TERSEY SARAH A (US)
EIZIRIK DECIO LAKS (BE)
FUKS FRANCOIS (BE)
TERSEY SARAH A (US)
EIZIRIK DECIO LAKS (BE)
FUKS FRANCOIS (BE)
Application Number:
PCT/US2016/043407
Publication Date:
June 08, 2017
Filing Date:
July 21, 2016
Export Citation:
Assignee:
UNIV INDIANA RES & TECH CORP (US)
UNIVERSITÉ LIBRE DE BRUXELLES (BE)
UNIVERSITÉ LIBRE DE BRUXELLES (BE)
International Classes:
C12Q1/68
Domestic Patent References:
| WO2002000928A2 | 2002-01-03 | |||
| WO2006070729A1 | 2006-07-06 |
Other References:
HEROLD ET AL.: "[beta] cell death and dysfunction during type 1 diabetes development in at-risk individuals.", J CLIN INVEST., vol. 125, no. 3, 2 March 2015 (2015-03-02), pages 1163 - 73, XP055388456
FISHER ET AL.: "Detection of Beta Cell Death in Serum of Persons with Type 1 and 2 Diabetes Using Multiplex PCR Analysis: Evaluation of a Potential Circulating Beta Cell Death Biomarker.", ENDOCRINE SOCIETY'S 96TH ANNUAL MEETING AND EXPO, 2014, pages SUN-0979, XP055388465
AKIRAV ET AL.: "Detection of beta cell death in diabetes using differentially methylated circulating DNA.", PROC NATL ACAD SCI USA, vol. 108, no. 47, 2011, pages 19018 - 19023, XP055162272
DATABASE NCBI [O] 30 March 1995 (1995-03-30), "Human gene for preproinsulin, from chromosome 11.", XP055388473, Database accession no. V00565
"Droplet Digital PCR. Applications Guide.", BIORAD., 2014, pages 46, Retrieved from the Internet [retrieved on 20161130]
FISHER ET AL.: "Detection of Beta Cell Death in Serum of Persons with Type 1 and 2 Diabetes Using Multiplex PCR Analysis: Evaluation of a Potential Circulating Beta Cell Death Biomarker.", ENDOCRINE SOCIETY'S 96TH ANNUAL MEETING AND EXPO, 2014, pages SUN-0979, XP055388465
AKIRAV ET AL.: "Detection of beta cell death in diabetes using differentially methylated circulating DNA.", PROC NATL ACAD SCI USA, vol. 108, no. 47, 2011, pages 19018 - 19023, XP055162272
DATABASE NCBI [O] 30 March 1995 (1995-03-30), "Human gene for preproinsulin, from chromosome 11.", XP055388473, Database accession no. V00565
"Droplet Digital PCR. Applications Guide.", BIORAD., 2014, pages 46, Retrieved from the Internet
Attorney, Agent or Firm:
KAZMIERSKI, Steven T. et al. (US)
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