Title:
CELL HAVING ABILITY TO FORM STRATIFIED EPITHELIAL TISSUE, AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2016/072105
Kind Code:
A1
Abstract:
[Problem] To convert directly from a somatic cell into a cell having the ability to form stratified epithelial tissue that can act as outer skin of the body. [Solution] A method for producing a cell having the ability to form stratified epithelial tissue, the method including a step for introducing into a somatic cell at least one gene expressed relatively strongly in a cell having the ability to form stratified epithelial tissue.
Inventors:
KURITA MASAKAZU (JP)
Application Number:
PCT/JP2015/059872
Publication Date:
May 12, 2016
Filing Date:
March 30, 2015
Export Citation:
Assignee:
KYORIN GAKUEN (JP)
International Classes:
C12N5/10; A01K67/027; A61K35/12; A61K48/00; A61P17/00; A61P27/02; C12M1/00; C12N15/00; C12N15/09; C12Q1/02; G01N33/15; G01N33/48; G01N33/50
Domestic Patent References:
| WO2005083075A1 | 2005-09-09 |
Foreign References:
| JP2008508968A | 2008-03-27 |
Other References:
MASAKAZU KURITA ET AL.: "Hifu Kaiyo Johika Sokushin o Mokuteki to shita Sen'iga Saibo kara Keratinocyte eno Chokusetsu Tenkan no Kokoromi", DAI 22 KAI JAPAN SOCIETY OF PLASTIC AND RECONSTRUCTIVE SURGERY KISO GAKUJUTSU SHUKAI PROGRAM SHOROKUSHU, 10 October 2013 (2013-10-10), pages 115
MASAKAZU KURITA ET AL.: "Idenshi Donyu ni yoru Sen'iga Saibo kara Keratinocyte eno Chokusetsu Tenkan Hoho no Kaihatsu", DAI 23 KAI JAPAN SOCIETY OF PLASTIC AND RECONSTRUCTIVE SURGERY KISO GAKUJUTSU SHUKAI PROGRAM SHOROKUSHU, 12 September 2014 (2014-09-12), pages 63
S.S.MCDADE ET AL.: "Genome-wide analysis of p63 binding sites identifies AP -2 factors as co- regulators of epidermal differentiation", NUCLEIC ACIDS RESEARCH, vol. 40, no. 15, 2012, pages 7190 - 7206, XP055278748
Y.BOGLEV ET AL.: "The unique and cooperative roles of the Grainy head-like transcription factors in epidermal developent reflect unexpected target gene specificity", DEVELOPMENTAL BIOLOGY, vol. 349, no. 2, 2011, pages 512 - 522, XP028150699
H.TSENG ET AL.: "Basonuclin in murine corneal and lens epithelia correlates with cellular maturation and proliferative ability", DIFFERENTIATION, vol. 65, no. 4, 1999, pages 221 - 227, XP026790095
K.A.HONEYCUTT ET AL.: "Genes Involved in Stem Cell Fate Decisions and Commitment to Differentiation Play a Role in Skin Disease", JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS, vol. 9, no. 3, 2004, pages 261 - 268, XP009110353
MASAKAZU KURITA ET AL.: "Idenshi Donyu ni yoru Sen'iga Saibo kara Keratinocyte eno Chokusetsu Tenkan Hoho no Kaihatsu", DAI 23 KAI JAPAN SOCIETY OF PLASTIC AND RECONSTRUCTIVE SURGERY KISO GAKUJUTSU SHUKAI PROGRAM SHOROKUSHU, 12 September 2014 (2014-09-12), pages 63
S.S.MCDADE ET AL.: "Genome-wide analysis of p63 binding sites identifies AP -2 factors as co- regulators of epidermal differentiation", NUCLEIC ACIDS RESEARCH, vol. 40, no. 15, 2012, pages 7190 - 7206, XP055278748
Y.BOGLEV ET AL.: "The unique and cooperative roles of the Grainy head-like transcription factors in epidermal developent reflect unexpected target gene specificity", DEVELOPMENTAL BIOLOGY, vol. 349, no. 2, 2011, pages 512 - 522, XP028150699
H.TSENG ET AL.: "Basonuclin in murine corneal and lens epithelia correlates with cellular maturation and proliferative ability", DIFFERENTIATION, vol. 65, no. 4, 1999, pages 221 - 227, XP026790095
K.A.HONEYCUTT ET AL.: "Genes Involved in Stem Cell Fate Decisions and Commitment to Differentiation Play a Role in Skin Disease", JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS, vol. 9, no. 3, 2004, pages 261 - 268, XP009110353
Attorney, Agent or Firm:
ISODA SHIRO (JP)
Shiro Isoda (JP)
Shiro Isoda (JP)
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