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Title:
CELL MIGRATION-PROMOTING ANTIBACTERIAL COATING FOR DENTAL IMPLANT AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/039933
Kind Code:
A1
Abstract:
A cell migration-promoting antibacterial coating for dental implants. The coating is a polypeptide monolayer film-grafted maleopimaric acid quaternary ammonium salt, and the grafting rate is 5-7%; the contact angle of the coating is 60-70°; the antibacterial rate of the coating for Escherichia coli is 86-91%, and the antibacterial rate of the coating for Staphylococcus aureus is 92-98%. Primary amino groups on a collagen polypeptide monolayer film are grafted with carboxyl groups on the maleopimaric acid quaternary ammonium salt under alkaline conditions, thereby introducing intrinsic functional groups of the quaternary ammonium salt into the collagen polypeptide monolayer film, so that antibacterial performance of the collagen polypeptide is improved; the maleopimaric acid quaternary ammonium salt also has resistance to pathogen attack, and the grafted maleopimaric acid quaternary ammonium salt can promote cell migration, so that the film is more suitable for dental implants.

Inventors:
XU JING (CN)
LI TIANDUO (CN)
GAO CHUNHONG (CN)
BAN QING (CN)
Application Number:
PCT/CN2021/120747
Publication Date:
March 23, 2023
Filing Date:
September 26, 2021
Export Citation:
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Assignee:
UNIV QILU TECHNOLOGY (CN)
International Classes:
A61L27/54; A61K6/20; A61L27/06
Foreign References:
CN111671970A2020-09-18
CN110734566A2020-01-31
CN111840661A2020-10-30
JP2020132590A2020-08-31
CN110776551A2020-02-11
Other References:
LI ZHAOSHUANG; LIU HE; XU XU; MA LINA; SHANG SHIBIN; SONG ZHANQIAN: "Surface modification of silicone elastomer with rosin acid-based quaternary ammonium salt for antimicrobial and biocompatible properties", MATERIALS & DESIGN, ELSEVIER, AMSTERDAM, NL, vol. 189, 16 January 2020 (2020-01-16), AMSTERDAM, NL , XP086088868, ISSN: 0264-1275, DOI: 10.1016/j.matdes.2020.108493
Attorney, Agent or Firm:
ZHUSEN INTELLECTUAL PROPERTY AGENCY OFFICE (CN)
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