Title:
CELL NECROSIS INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/001420
Kind Code:
A1
Abstract:
Provided by the present application are a cell necrosis inhibitor, a preparation method therefor and a use thereof; in particular, provided by the present application is an inhibitor of cell necrosis and/or human receptor-interacting protein 1 kinase (RIP1). The inhibitor has a structure as shown in the following formula I. The compound and a composition comprising same may be used to prevent and/or treat diseases involving cell death and/or inflammation. (I)
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Inventors:
MA DAWEI (CN)
JI YUHUA (CN)
HE WEIMING (CN)
FANG CHAO (CN)
ZHAO JINLONG (CN)
WANG KAILIANG (CN)
XIA SHANGHUA (CN)
LI ZHENG (CN)
LI YING (CN)
JI YUHUA (CN)
HE WEIMING (CN)
FANG CHAO (CN)
ZHAO JINLONG (CN)
WANG KAILIANG (CN)
XIA SHANGHUA (CN)
LI ZHENG (CN)
LI YING (CN)
Application Number:
PCT/CN2019/092705
Publication Date:
January 02, 2020
Filing Date:
June 25, 2019
Export Citation:
Assignee:
SHANGHAI INST ORGANIC CHEMISTRY CAS (CN)
International Classes:
A61K31/55; C07D403/12; A61P1/00; A61P11/00; C07D413/12; C07D471/04; C07D487/04; C07D491/04; C07D495/04; C07D498/04
Domestic Patent References:
| WO2017109724A1 | 2017-06-29 | |||
| WO2018109097A1 | 2018-06-21 | |||
| WO2018073193A1 | 2018-04-26 | |||
| WO2017069279A1 | 2017-04-27 |
Foreign References:
| CN105121432A | 2015-12-02 | |||
| CN106573006A | 2017-04-19 | |||
| CN107849023A | 2018-03-27 |
Other References:
"Handbook of Chemistry and Physics", article "Periodic Table of the Elements, CAS version"
T. W. GREENEP. G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, UNIVERSITY SCIENCE BOOKS
SMITH, M.B.MARCH, J.: "March's Advanced Organic Chemistry", 2001, JOHN WILEY & SONS
P. G. M. WUTST. W. GREENE: "Greene's Protective Groups in Organic Synthesis", 2006, WILEY-INTERSCIENCE
JACQUES ET AL.: "Enantiomers, Racemates and Resolutions", 1981, WILEY INTERSCIENCE
WILEN, S.H. ET AL., TETRAHEDRON, vol. 33, 1977, pages 2725
ELIEL, E.L.: "Stereochemistry of Carbon Compounds", 1962, MCGRAW-HILL
WILEN, S.H.: "Tables of Resolving Agents and Optical Resolutions", 1972, UNIV. OF NOTRE DAME PRESS, pages: 268
T. HIGUCHIV. STELLA: "A.C.S. Symposium Series, and Bioreversible Carriers in Drug Design", vol. 14, 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS, article "Prodrugs as Novel Delivery Systems"
BERTOLINI ET AL., J MED CHEM, vol. 40, 1997, pages 2011 - 2016
SHAN ET AL., J PHARM SCI, vol. 86, pages 756 - 757
BAGSHAWE, DRUGDEV RES, vol. 34, 1995, pages 220 - 230
"Remington's Pharmaceutical Sciences", vol. 2, 1995, MACK PUBLISHING CO., pages: 1457
STAHLWERMUTH: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
"Medical Applications of Controlled Release", 1974, CRC PRES.
"Drug Product Design and Performance", 1984, WILEY, article "Controlled Drug Bioavailability"
RANGERPEPPAS, J MACROMOL. SCI. REV. MACROMOL CHEM., vol. 23, 1983, pages 61
LEVY ET AL., SCIENCE, vol. 228, 1985, pages 190
DURING ET AL., ANN. NEUROL., vol. 25, 1989, pages 351
HOWARD ET AL., J. NEUROSURG., vol. 71, 1989, pages 105
See also references of EP 3816163A4
T. W. GREENEP. G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, UNIVERSITY SCIENCE BOOKS
SMITH, M.B.MARCH, J.: "March's Advanced Organic Chemistry", 2001, JOHN WILEY & SONS
P. G. M. WUTST. W. GREENE: "Greene's Protective Groups in Organic Synthesis", 2006, WILEY-INTERSCIENCE
JACQUES ET AL.: "Enantiomers, Racemates and Resolutions", 1981, WILEY INTERSCIENCE
WILEN, S.H. ET AL., TETRAHEDRON, vol. 33, 1977, pages 2725
ELIEL, E.L.: "Stereochemistry of Carbon Compounds", 1962, MCGRAW-HILL
WILEN, S.H.: "Tables of Resolving Agents and Optical Resolutions", 1972, UNIV. OF NOTRE DAME PRESS, pages: 268
T. HIGUCHIV. STELLA: "A.C.S. Symposium Series, and Bioreversible Carriers in Drug Design", vol. 14, 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS, article "Prodrugs as Novel Delivery Systems"
BERTOLINI ET AL., J MED CHEM, vol. 40, 1997, pages 2011 - 2016
SHAN ET AL., J PHARM SCI, vol. 86, pages 756 - 757
BAGSHAWE, DRUGDEV RES, vol. 34, 1995, pages 220 - 230
"Remington's Pharmaceutical Sciences", vol. 2, 1995, MACK PUBLISHING CO., pages: 1457
STAHLWERMUTH: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
"Medical Applications of Controlled Release", 1974, CRC PRES.
"Drug Product Design and Performance", 1984, WILEY, article "Controlled Drug Bioavailability"
RANGERPEPPAS, J MACROMOL. SCI. REV. MACROMOL CHEM., vol. 23, 1983, pages 61
LEVY ET AL., SCIENCE, vol. 228, 1985, pages 190
DURING ET AL., ANN. NEUROL., vol. 25, 1989, pages 351
HOWARD ET AL., J. NEUROSURG., vol. 71, 1989, pages 105
See also references of EP 3816163A4
Attorney, Agent or Firm:
JUN HE LAW OFFICES (CN)
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