Title:
CELL STRAIN FOR TREATING MELANOMA, AND MULTI-TITER WHOLE-CELL VACCINE THEREOF AND USE METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/246109
Kind Code:
A1
Abstract:
Provided are a cell strain for treating melanoma, and a multi-titer whole-cell vaccine prepared therefrom and a use method. The multi-titer whole-cell vaccine is prepared by means of mixing a ZJMM-45 homologous human melanoma cell strain with the deposit number CCTCC NO: C2022105 and a FLFMM-34 homologous human melanoma cell strain with the deposit number CCTCC NO: C2022100 in a molar ratio of 1:1. The multi-titer whole-cell vaccine can increase the specific anti-tumor immune response of malignant melanoma vaccines for the Han Chinese population, and obviously improve the total survival rate of patients.
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Inventors:
GAO TIANWEN (CN)
GUO WEINAN (CN)
LIU YING (CN)
GUO WEINAN (CN)
LIU YING (CN)
Application Number:
PCT/CN2023/074440
Publication Date:
December 28, 2023
Filing Date:
February 03, 2023
Export Citation:
Assignee:
AIR FORCE MEDICAL UNIV (CN)
International Classes:
A61K38/21; C12N5/09; A61K39/00; A61K39/04; A61P35/00; C12N5/071
Foreign References:
| CN115074328A | 2022-09-20 | |||
| CN110694055A | 2020-01-17 | |||
| US20100183683A1 | 2010-07-22 | |||
| US5882654A | 1999-03-16 |
Other References:
HU CHEN, ZHANG BIN: "Immunotherapy of melanoma:An update", CHINESE JOURNAL OF CANCER BIOTHERAPY, PUBLISHING HOUSE OF CHINESE JOURNAL OF CANCER BIOTHERAPY, CN, vol. 20, no. 3, 20 June 2013 (2013-06-20), CN , pages 365 - 371, XP093119406, ISSN: 1007-385X
ELIZA KWIATKOWSKA-BOROWCZYK, CZERWIńSKA PATRYCJA, MACKIEWICZ JACEK, GRYSKA KATARZYNA, KAZIMIERCZAK URSZULA, TOMELA KATARZYNA,: "Whole cell melanoma vaccine genetically modified to stem cells like phenotype generates specific immune responses to ALDH1A1 and long-term survival in advanced melanoma patients", ONCOIMMUNOLOGY, vol. 7, no. 11, 24 August 2018 (2018-08-24), pages e1509821, XP055730808, DOI: 10.1080/2162402X.2018.1509821
LIU YING, YI XIULI, YE ZHUBIAO, GAO TIANWEN, ZHU GUANNAN : "Establishment of a Novel Chinese Metastatic Melanoma Cell Line and Analysis of Its Biological Characteristics", ZHONGHUA PIFUKE ZAZHI - CHINESE JOURNAL OF DERMATOLOGY, ZHONGGUO YIXUE KEXUEYUAN PIFUBING YANJIUSUO, NANJING, CN, vol. 55, no. 5, 15 May 2022 (2022-05-15), CN , pages 375 - 381, XP009551305, ISSN: 0412-4030, DOI: 10.35541/cjd.20210332
ELIZA KWIATKOWSKA-BOROWCZYK, CZERWIńSKA PATRYCJA, MACKIEWICZ JACEK, GRYSKA KATARZYNA, KAZIMIERCZAK URSZULA, TOMELA KATARZYNA,: "Whole cell melanoma vaccine genetically modified to stem cells like phenotype generates specific immune responses to ALDH1A1 and long-term survival in advanced melanoma patients", ONCOIMMUNOLOGY, vol. 7, no. 11, 24 August 2018 (2018-08-24), pages e1509821, XP055730808, DOI: 10.1080/2162402X.2018.1509821
LIU YING, YI XIULI, YE ZHUBIAO, GAO TIANWEN, ZHU GUANNAN : "Establishment of a Novel Chinese Metastatic Melanoma Cell Line and Analysis of Its Biological Characteristics", ZHONGHUA PIFUKE ZAZHI - CHINESE JOURNAL OF DERMATOLOGY, ZHONGGUO YIXUE KEXUEYUAN PIFUBING YANJIUSUO, NANJING, CN, vol. 55, no. 5, 15 May 2022 (2022-05-15), CN , pages 375 - 381, XP009551305, ISSN: 0412-4030, DOI: 10.35541/cjd.20210332
Attorney, Agent or Firm:
CHONGQING ZHICHENG DABANG PATENT AGENCY OFFICE (GENERAL PARTNERSHIP) (CN)
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