CELL-SURFACE ESTROGEN RECEPTOR AND RELATED COMPOSITIONS AND METHODS

Title:

CELL-SURFACE ESTROGEN RECEPTOR AND RELATED COMPOSITIONS AND METHODS

Document Type and Number:

WIPO Patent Application WO2004029023

Kind Code:

A3

Abstract:

This invention provides an isolated mammalian cell-surface estrogen receptor characterized by (a) a nonstereospecific binding affinity for 17alpha-estradiol and 17beta-estradiol; (b) at least one epitope in common with the ligand-binding domain of ER-a; and (c) increased presence at caveolar or caveolar-like microdomains of cells on which the receptor is present. This invention further provides related methods for assaying compounds, activating the MAP kinase pathway of a cell, and delaying the onset of or treating disorders. Finally, this invention provides related articles and compositions of matter.

Inventors:

TORAN-ALLERAND C DOMINIQUE

Application Number:

PCT/US2003/029177

Publication Date:

August 05, 2004

Filing Date:

September 19, 2003

Export Citation:

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Assignee:

UNIV COLUMBIA (US)

International Classes:

C07H21/04; C07K14/705; C07K14/72; C12Q1/68; G01N33/53; G01N33/567; A61K38/00; (IPC1-7): C07H21/04; C07K14/705; C12N15/09; C12N15/63; C12Q1/68

Domestic Patent References:

WO2004029023A2

2004-04-08

Foreign References:

US6566081B1	2003-05-20
US20030225046A1	2003-12-04
US5298429A	1994-03-29

Other References:

THORNTON M.J.: "The biological actions of estrogen on skin", EXPERIMENTAL DERMATOLOGY, vol. 11, 2002, pages 487 - 502, XP002978156
STEFANO G.B.: "Cell-surface estrogen receptors mediate calcium-dependent nitric oxide release in human endothelia", CIRCULATION, vol. 101, 4 April 2000 (2000-04-04), pages 1594 - 1597, XP002978157

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