Title:
CELL- OR TISSUE-EMBEDDING DEVICE
Document Type and Number:
WIPO Patent Application WO/2018/155622
Kind Code:
A1
Abstract:
By suppressing the loss of living cells or living tissue during the production of a PVA gel that contains living cells or living tissue, the present invention addresses the problem of supplying a cell- or tissue-embedding device that has a high capacity for supplying a biologically active substance. According to the present invention, an aqueous gel for forming an immunoisolation layer for a cell- or tissue-embedding device is formed from a polyvinyl alcohol resin that has a triad syndiotacticity of 32%–40%.
Inventors:
OHARUDA AKINOBU (JP)
KIMURA YOSHIHIRO (JP)
GOTO MASAFUMI (JP)
KIMURA YOSHIHIRO (JP)
GOTO MASAFUMI (JP)
Application Number:
PCT/JP2018/006662
Publication Date:
August 30, 2018
Filing Date:
February 23, 2018
Export Citation:
Assignee:
JAPAN VAM & POVAL CO LTD (JP)
NATIONAL UNIV CORPORATION TOHOKU UNIV (JP)
NATIONAL UNIV CORPORATION TOHOKU UNIV (JP)
International Classes:
C12M3/00; A61K35/12; A61K35/22; A61K35/26; A61K35/28; A61K35/30; A61K35/39; A61K35/407; A61K35/545; A61K35/55; C12N11/04; A61P3/00; A61P5/00
Foreign References:
| JP2003102748A | 2003-04-08 | |||
| JPH1192524A | 1999-04-06 | |||
| JPH1072509A | 1998-03-17 | |||
| JPH1043286A | 1998-02-17 | |||
| JP2004331643A | 2004-11-25 |
Other References:
SUMI, S. ET AL.: "Review: Macro-Encapsulation of Islets in Polyvinyl Alcohol Hydrogel", JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING, vol. 34, no. 3, 1 January 2014 (2014-01-01), pages 204 - 210, XP055536974, DOI: 10.5405/jmbe.1579
INAGAKI, AKIKO ET AL.: "Evaluation of in-vitro immunoisolation function in immunoisolation device for cell transplantation, composed of hydrogel", REGENERATIVE MEDICINE, vol. 16, 1 February 2017 (2017-02-01), pages 317, XP009516425
KRYSTYNA BURCZAK ET AL.: "Long-term in vivo performance and biocompatibility of PVA hydrogelmacrocapsules for hybrid-type artificial pancreas", BIOMATERIALS, vol. 17, 1996, pages 2351 - 2356
See also references of EP 3587555A4
INAGAKI, AKIKO ET AL.: "Evaluation of in-vitro immunoisolation function in immunoisolation device for cell transplantation, composed of hydrogel", REGENERATIVE MEDICINE, vol. 16, 1 February 2017 (2017-02-01), pages 317, XP009516425
KRYSTYNA BURCZAK ET AL.: "Long-term in vivo performance and biocompatibility of PVA hydrogelmacrocapsules for hybrid-type artificial pancreas", BIOMATERIALS, vol. 17, 1996, pages 2351 - 2356
See also references of EP 3587555A4
Attorney, Agent or Firm:
IWATANI, Ryo (JP)
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