CELLS COMPRISING A SUPPRESSOR OF GENE EXPRESSION AND/OR A SYNTHETIC PATHWAY ACTIVATOR AND/OR AN INDUCIBLE PAYLOAD

Title:

CELLS COMPRISING A SUPPRESSOR OF GENE EXPRESSION AND/OR A SYNTHETIC PATHWAY ACTIVATOR AND/OR AN INDUCIBLE PAYLOAD

Document Type and Number:

WIPO Patent Application WO/2023/205724

Kind Code:

A3

Abstract:

Provided herein are systems comprising one or both of cytokines and/or synthetic pathway activators. Also provided herein are systems comprising one or more suppressors of gene expression, and one or both of cytokines and/or synthetic pathway activators. Also provided are systems of chimeric priming receptors that bind ALPG and/or ALPP, chimeric antigen receptors that bind MSLN, and at least one of one or more suppressors of gene expression, and/or one or both of cytokines and/or synthetic pathway activators; cells expressing such systems; and methods of use thereof.

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Inventors:

COOPER AARON (US)
CHOE JOSEPH (US)
KYRIAZOPOULOU PANAGIOTOPO SOFIA (US)
SANDOVAL MARIAN (US)
SHAVEY GAVIN (US)
SANTORO STEPHEN (US)
CASSEREAU LUKE (US)
HSU BRIAN (US)
HALL JASON (US)
BEZMAN NATALIE (US)
GARDNER THOMAS (US)
YAO ANZHI (US)

Application Number:

PCT/US2023/065998

Publication Date:

November 30, 2023

Filing Date:

April 20, 2023

Export Citation:

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Assignee:

ARSENAL BIOSCIENCES INC (US)

International Classes:

C07K14/705; A61K39/00; C07K14/725; A61K48/00

Domestic Patent References:

WO2022047237A1	2022-03-03
WO2021096783A1	2021-05-20
WO2023064928A2	2023-04-20

Foreign References:

US20210023139A1

2021-01-28

Attorney, Agent or Firm:

WIENS, Mayim E. et al. (US)

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