Title:
CELLS EXPRESSING FAS LIGAND POLYPEPTIDES AND FAS KNOCKOUT AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/122235
Kind Code:
A3
Abstract:
The presently disclosed subject matter provides cells, compositions and methods for enhancing immune responses toward tumor. It relates to cells comprising: an antigen-recognizing receptor (e.g., a chimeric antigen receptor, a TCR, or a TCR like fusion molecule), a Fas ligand polypeptide (FasL), and a gene disruption of a Fas locus. The gene disruption of the Fas locus can improve the activity and/or efficiency of the cells. The presently disclosed cells, compositions, and methods can be used in allogeneic settings.
Inventors:
SADELAIN MICHEL (US)
PERICA KARLO (US)
PERICA KARLO (US)
Application Number:
PCT/US2022/053750
Publication Date:
August 03, 2023
Filing Date:
December 22, 2022
Export Citation:
Assignee:
MEMORIAL SLOAN KETTERING CANCER CENTER (US)
SLOAN KETTERING INST CANCER RES (US)
MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES (US)
SLOAN KETTERING INST CANCER RES (US)
MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES (US)
International Classes:
C07K14/705; C07K14/725; A61K38/00; C07K14/525
Domestic Patent References:
| WO2021141985A1 | 2021-07-15 |
Foreign References:
| US20210169929A1 | 2021-06-10 | |||
| US6951919B1 | 2005-10-04 |
Other References:
VOSS MATTHIAS; LETTAU MARCUS; PAULSEN MAREN; JANSSEN OTTMAR: "Posttranslational regulation of Fas ligand function", CELL COMMUNICATION AND SIGNALING, BIOMED CENTRAL, LONDON, GB, vol. 6, no. 1, 29 December 2008 (2008-12-29), GB , pages 11, XP021050572, ISSN: 1478-811X, DOI: 10.1186/1478-811X-6-11
Attorney, Agent or Firm:
LENDARIS, Steven, P. et al. (US)
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