Title:
CELLULAR IMMUNOTHERAPY COMBINATION
Document Type and Number:
WIPO Patent Application WO/2020/143631
Kind Code:
A1
Abstract:
Disclosed is a tumor treatment method, characterized in that immune effector cells and gemcitabine are administered to an individual with a tumor, and the immune effector cells express receptors having a tumor-specific antigen. Also disclosed is a tumor treatment kit, characterized in that the kit comprises 1) immune effector cells expressing receptors that recognize tumor antigens; 2) gemcitabine; 3) a container for for containing the substances of 1) and 2) described above; and 4) drug administration instructions for using the kit to treat a tumor.
Inventors:
LI ZONGHAI (CN)
WU XIUQI (CN)
WU XIUQI (CN)
Application Number:
PCT/CN2020/070717
Publication Date:
July 16, 2020
Filing Date:
January 07, 2020
Export Citation:
Assignee:
CARSGEN THERAPEUTICS CO LTD (CN)
SHANGHAI CANCER INST (CN)
SHANGHAI CANCER INST (CN)
International Classes:
A61K35/17
Domestic Patent References:
| WO2017186121A1 | 2017-11-02 | |||
| WO2018006882A1 | 2018-01-11 | |||
| WO2015172339A1 | 2015-11-19 | |||
| WO2018018958A1 | 2018-02-01 |
Foreign References:
| CN108853144A | 2018-11-23 | |||
| CN107960056A | 2018-04-24 | |||
| US4683195A | 1987-07-28 | |||
| CN107058354A | 2017-08-18 | |||
| CN107460201A | 2017-12-12 | |||
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| CN106397593A | 2017-02-15 | |||
| CN106467573A | 2017-03-01 | |||
| CN104140974A | 2014-11-12 |
Other References:
AOKI, T. ET AL.: "Adjuvant combination therapy with gemcitabine and auto- logous y deltaT- cell transfer in patients with curatively resected pancreatic cancer", CYTOTHERAPY, vol. 19, no. 4, 1 April 2017 (2017-04-01), pages 473 - 485, XP055725466
ENBLAD, G. ET AL.: "CAR T- Cell Therapy: The Role of Physical Barriers and Immunosuppression in Lymphoma", HUMAN GENE THERAPY, vol. 26, no. 8, 1 August 2015 (2015-08-01), XP055725467
YUAN XIANG-QING,CUI CHUAN-LIANG,SI LU: "Phase II Clinical Trial of Chemotherapy Combined with Autologous CIK Cells Transfusion in the Treatment for Metastatic Renal Cell Carcinoma", JOURNAL OF CHINESE ONCOLOGY, vol. 14, no. 5, 20 May 2008 (2008-05-20), pages 362 - 365, XP055831420
SHAO-PEI YU, JING YANG: "Gemcitabine in combination with dendritic cell-induced immunoeffector cells inhibits the growth of BxPC-3 cells", WORLD CHINESE JOURNAL OF DIGESTOLOGY, SHIJE WEI-CHANGBINGXUE ZAZHISHE , TAIYUAN, CN, vol. 18, no. 20, 18 July 2018 (2018-07-18), CN, pages 2095 - 2101, XP009529340, ISSN: 1009-3079
JESSICA HARTMANN ET AL., EMBO MOLECULE MEDICINE, 1 August 2017 (2017-08-01)
FREDERICKMAUSUBEL: "Library of Congress,USA", 2000, WILEYAND SONINC, article "Current Protocols in Molecular Biology"
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
M.J.GAITED., OLIGONUCLEOTIDE SYNTHESIS, 1984
B. PERBAL, A PRACTICAL GUIDE TO MOLECULAR CLONING, 1984
R. I. FRESHNEYALAN R: "Immunochemical Methods In Cell And Molecular Biology", 1987, COLD SPRING HARBOR LABORATORY
"Hand book Of Experimental Immunology", vol. I-IV, 1986, COLD SPRING HARBOR LABORATORY PRESS
Academic Press,Inc.; "GenBank", Database accession no. AAA62478.2
"Molecular Cloning Experiment Guide (Third Edition", 2002, SCIENCE PRESS
See also references of EP 3909590A4
ENBLAD, G. ET AL.: "CAR T- Cell Therapy: The Role of Physical Barriers and Immunosuppression in Lymphoma", HUMAN GENE THERAPY, vol. 26, no. 8, 1 August 2015 (2015-08-01), XP055725467
YUAN XIANG-QING,CUI CHUAN-LIANG,SI LU: "Phase II Clinical Trial of Chemotherapy Combined with Autologous CIK Cells Transfusion in the Treatment for Metastatic Renal Cell Carcinoma", JOURNAL OF CHINESE ONCOLOGY, vol. 14, no. 5, 20 May 2008 (2008-05-20), pages 362 - 365, XP055831420
SHAO-PEI YU, JING YANG: "Gemcitabine in combination with dendritic cell-induced immunoeffector cells inhibits the growth of BxPC-3 cells", WORLD CHINESE JOURNAL OF DIGESTOLOGY, SHIJE WEI-CHANGBINGXUE ZAZHISHE , TAIYUAN, CN, vol. 18, no. 20, 18 July 2018 (2018-07-18), CN, pages 2095 - 2101, XP009529340, ISSN: 1009-3079
JESSICA HARTMANN ET AL., EMBO MOLECULE MEDICINE, 1 August 2017 (2017-08-01)
FREDERICKMAUSUBEL: "Library of Congress,USA", 2000, WILEYAND SONINC, article "Current Protocols in Molecular Biology"
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
M.J.GAITED., OLIGONUCLEOTIDE SYNTHESIS, 1984
B. PERBAL, A PRACTICAL GUIDE TO MOLECULAR CLONING, 1984
R. I. FRESHNEYALAN R: "Immunochemical Methods In Cell And Molecular Biology", 1987, COLD SPRING HARBOR LABORATORY
"Hand book Of Experimental Immunology", vol. I-IV, 1986, COLD SPRING HARBOR LABORATORY PRESS
Academic Press,Inc.; "GenBank", Database accession no. AAA62478.2
"Molecular Cloning Experiment Guide (Third Edition", 2002, SCIENCE PRESS
See also references of EP 3909590A4
Attorney, Agent or Firm:
BEIJING CAI HE LAW FIRM (CN)
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