CEPHALOMANNINE DERIVATIVES AND THEIR PREPARATION, MEDICINAL COMPOSITION AND USE

Title:

CEPHALOMANNINE DERIVATIVES AND THEIR PREPARATION, MEDICINAL COMPOSITION AND USE

Document Type and Number:

WIPO Patent Application WO/2009/062342

Kind Code:

A1

Abstract:

Cephalomannine derivatives of formula(I),their preparation, the composition including them, and their use of manufacturing of anti-tumor medicaments, especially of the medicaments against multidrug resistant tumor.

Inventors:

FANG WEISHUO (CN)
CHEN XIAOGUANG (CN)
YANG CHUNGANG (CN)
LI XUAN (CN)
WANG HONGBO (CN)
LIU HONGYAN (CN)
HAN RUI (CN)
ZHAO LIMIN (CN)

Application Number:

PCT/CN2007/003235

Publication Date:

May 22, 2009

Filing Date:

November 15, 2007

Export Citation:

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Assignee:

INST OF MATARIA MEDICA CHINESE (CN)
FANG WEISHUO (CN)
CHEN XIAOGUANG (CN)
YANG CHUNGANG (CN)
LI XUAN (CN)
WANG HONGBO (CN)
LIU HONGYAN (CN)
HAN RUI (CN)
ZHAO LIMIN (CN)

International Classes:

C07D305/14; A61K31/337; A61P35/00

Foreign References:

US20050240036A1	2005-10-27
CN1234700C	2006-01-04
CN101074218A	2007-11-21
US4814470A	1989-03-21

Other References:

EUN JOO ROH ET AL.: "Structure-Activity Relationship Study at the 3'-N-Position of Paclitaxel : Synthesis and Biological Evaluation of 3'-N-Acyl-Paclitaxel Analogues", BIOORGANIC &MEDICINAL CHEMISTRY, 2002, pages 3145 - 3151, XP008134422
MAGRIN.F. ET AL.: "Modified Taxols. 3.Preparation and Acylation of Baccatin III", J. ORG. CHEM., 1986, pages 3239 - 3242, XP001013269
SCHIFF, P. B.; FANT, J.; HORWITZ S. B, NATURE, vol. 277, 1979, pages 665
See also references of EP 2213667A4

Attorney, Agent or Firm:

BEIJING SAN GAO YONG XIN INTELLECTUAL PROPERTY AGENCY CO., LTD (No.1 BuildingJi Men Li, He Jing Yuan,Xueyuan Road,Haidian District, Beijing 8, CN)

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