Title:
CEPHALOSPORIN COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/1993/011131
Kind Code:
A1
Abstract:
beta-lactam antibiotics of formula (I) or a salt thereof, wherein R1 is hydrogen, methoxy of formamido; R2 is an acyl group, in particular that of an antibacterially active cephalosporin; CO2R3 is a carboxy group or a carboxylate anion, or R3 is a readily removable carboxy protecting group (such as a pharmaceutically acceptable in vivo hydrolysable ester group); R4 represents up to four substituents selected from alkyl, alkenyl, alkynyl, alkoxy, hydroxy, halogen, amino, alkylamino, acylamino, dialkylamino, CO2R, CONR2, SO2NR2 (where R is hydrogen or C1-6 alkyl), aryl and heterocyclyl, which may be the same or different and wherein any R4 alkyl substituent is optionally substituted by any other R4 substituent; X is S, SO, SO2, O or CH2; Y is S, SO or SO2; and m is 1 or 2, useful in the treatment of bacterial infections in humans and animals.
Inventors:
BURTON GEORGE (GB)
FELL STEPHEN CHRISTOPHER MARTI (GB)
FELL STEPHEN CHRISTOPHER MARTI (GB)
Application Number:
PCT/GB1992/002231
Publication Date:
June 10, 1993
Filing Date:
December 01, 1992
Export Citation:
Assignee:
SMITHKLINE BEECHAM PLC (GB)
International Classes:
A61K31/545; A61K31/546; A61P31/04; C07D498/04; C07D501/00; C07D501/18; C07D501/20; C07D501/24; (IPC1-7): A61K31/435; A61K31/535; A61K31/545; C07D463/00; C07D498/053; C07D501/18; C07D501/20
Domestic Patent References:
| WO1992001696A1 | 1992-02-06 | |||
| WO1992004353A1 | 1992-03-19 |
Foreign References:
| EP0392796A2 | 1990-10-17 | |||
| EP0395219A2 | 1990-10-31 |
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