Title:
CETP ACTIVITY INHIBITORS
Document Type and Number:
WIPO Patent Application WO/1998/035937
Kind Code:
A1
Abstract:
CETP activity inhitors containing as the active ingredient compounds represented by general formula (I), prodrug compounds thereof, pharmaceutically acceptable salts thereof, or hydrates or solvates of these, (wherein R represents linear or branched alkyl, linear or branched alkenyl, lower haloalkyl, optionally substitued cycloalkyl, optionally substituted cycloalkenyl, optionally substituted cycloalkylalkyl, optionally substitued aryl or optionally substituted heterocycle; X�1?, X�2?, X�3? and X�4? may be the same or different from each other and each represents hydrogen, halogeno, lower alkyl, lower haloalkyl, lower alkoxy, cyano, nitro, acyl or aryl; Y represents -CO- or -SO�2?-; and Z represents hydrogen or a mercapto-protective group). The compounds represented by general formula (I) are expected to be useful as preventives or remedies of a novel type for arteriosclerosis or hyperlipemia, since they can selectively inhibit the CETP activity to thereby increase HDL and, at the same time, decrease LDL.
Inventors:
SHINKAI HISASHI (JP)
MAEDA KIMIYA (JP)
OKAMOTO HIROSHI (JP)
MAEDA KIMIYA (JP)
OKAMOTO HIROSHI (JP)
Application Number:
PCT/JP1998/000542
Publication Date:
August 20, 1998
Filing Date:
February 10, 1998
Export Citation:
Assignee:
JAPAN TOBACCO INC (JP)
SHINKAI HISASHI (JP)
MAEDA KIMIYA (JP)
OKAMOTO HIROSHI (JP)
SHINKAI HISASHI (JP)
MAEDA KIMIYA (JP)
OKAMOTO HIROSHI (JP)
International Classes:
A61K31/165; A61K31/167; A61K31/18; A61K31/215; A61K31/34; A61K31/341; A61K31/38; A61K31/381; A61K31/40; A61K31/44; A61K31/4406; A61K31/4409; A61K31/445; A61P3/06; A61P9/10; A61P43/00; C07D333/38; C07C323/40; C07C323/41; C07C323/42; C07C323/63; C07C323/65; C07C327/30; C07C329/10; C07C329/20; C07C333/08; C07D207/16; C07D207/28; C07D211/34; C07D211/62; C07D213/81; C07D213/82; C07D307/10; C07D307/68; C07D521/00; (IPC1-7): C07C323/40; C07C323/63; C07C323/65; C07D207/16; C07D207/28; C07D211/62; C07D213/81; C07D307/68; C07D333/38; A61K31/165; A61K31/18; A61K31/255; A61K31/34; A61K31/38; A61K31/40; A61K31/44
Domestic Patent References:
| WO1995001326A1 | 1995-01-12 | |||
| WO1992003412A2 | 1992-03-05 | |||
| WO1992003408A1 | 1992-03-05 |
Foreign References:
| EP0632036A2 | 1995-01-04 | |||
| EP0796846A1 | 1997-09-24 |
Other References:
See also references of EP 1020439A4
Attorney, Agent or Firm:
Shimizu, Hatsushi (6F 1-1-1, Oroshi-mach, Tsuchiura-shi Ibaraki, JP)
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