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Title:
CH2 DOMAIN TEMPLATE MOLECULES DERIVED FROM RATIONAL GRAFTING OF DONOR LOOPS ONTO CH2 SCAFFOLDS
Document Type and Number:
WIPO Patent Application WO/2012/109553
Kind Code:
A3
Abstract:
Novel CH2 domain template molecules wherein donor loops from a database of domains are transferred to a CH2 domain scaffold. At least one or up to three loops from a donor are transferred to the CH2 domain. The donor loops may be chosen based on length, e.g., the donor loop may have a length that is similar to that of a structural loop in the CH2 domain scaffold.

Inventors:
BRAMHILL DAVID (US)
RAGHUNATHAN GOPALAN (US)
Application Number:
PCT/US2012/024675
Publication Date:
January 03, 2013
Filing Date:
February 10, 2012
Export Citation:
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Assignee:
RES CORP TECHNOLOGIES INC (US)
BRAMHILL DAVID (US)
RAGHUNATHAN GOPALAN (US)
International Classes:
A61K39/395
Foreign References:
US20100316641A12010-12-16
US20100074901A12010-03-25
US20100272720A12010-10-28
US20090298195A12009-12-03
US20090118127A12009-05-07
Other References:
See also references of EP 2672995A4
Attorney, Agent or Firm:
NGUYEN, Quan (4199 Campus DriveSuite 55, Irvine CA, US)
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