Title:
CHALCONE DERIVATIVES AND THEIR USE IN TREATING CANCER
Document Type and Number:
WIPO Patent Application WO/2015/166040
Kind Code:
A3
Abstract:
The present application relates to a compound of formula (I) for use in the prevention or treatment of cancer, wherein rings A and B are independently an aryl or a heteroaryl, wherein the aryl and/or the heteroaryl are optionally substituted with one or more substitutents selected from the group consisting of aliphatic, alkoxy, thioalkyl, alkylamino, halogen, hydroxy, cyano, nitro, hydroxyalkyl, alkylcarbonyloxy, alkoxycarbonyl, alkylcarbonyl, haloalkyl, alkylsulfonylamino NH2, NO2, SO2RX, SORX and COORX, where RX is hydrogen, aliphatic or aryl. The compounds are particularly provided for the prevention and/or treatment of cancer of the lung, colon, pancreas, liver and/or kidney.
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Inventors:
CHAUDHURI BHABATOSH (GB)
Application Number:
PCT/EP2015/059500
Publication Date:
January 14, 2016
Filing Date:
April 30, 2015
Export Citation:
Assignee:
UNIV MONTFORT (GB)
International Classes:
A61K31/4409; A61P35/00; C07D211/00
Domestic Patent References:
| WO2008156783A2 | 2008-12-24 | |||
| WO2008069608A1 | 2008-06-12 | |||
| WO2013054998A1 | 2013-04-18 |
Foreign References:
| US6096753A | 2000-08-01 |
Other References:
LASTERRA-SANCHEZ ET AL.: "DEVELOPEMENT OF THE JULIA ASYMETRIC EPOXIDATION REACTION. PART 1. APPLICATION OF THE OXIDATION TO ENONES OTHER THAN CHALCONES", J. CHEM. SOC., vol. 1, 1 January 1996 (1996-01-01), pages 343 - 348, XP002742645
MARVEL ET AL.: "PYRIDINE ANALOGS OF CHALCONE AND THEIR POLYMERIZATION REACTIONS", JOURNAL OF ORGANIC CHEMISTRY, vol. 20, no. 12, 1955, pages 1785 - 1792, XP002742646
KOK WAI LAM ET AL.: "SYNTHESIS AND QSAR ANALYSIS OF CHALCONE DERIVATIVES AS NITRIC OXIDE INHIBITORY AGENT", MED. CHEM. RES., vol. 21, 2012, pages 1953 - 1966, XP002742648
SHINJI YAMADA ET AL.: "CATION -PI CONTROLLED SOLID-STATE PHOTODIMERIZATION OF 4-AZACHALCONES", JACS, vol. 131, 2009, pages 2098 - 2099, XP002742647
VIEWEG U A H: "Synthese neuer heterocyclisch substituierter 2-Thioxo-1,2-dihydro-pyridin-3-carbonitrile", DIE PHARMAZIE, vol. 44, no. 9, 1 January 1989 (1989-01-01), GOVI VERLAG PHARMAZEUTISCHER VERLAG GMBH, ESCHBORN, DE, pages 639 - 640, XP001526717, ISSN: 0031-7144
PATHI SUMAN ET AL.: "MICROWAVE-ASSISTED CONVENIENT SYNTHESIS OF ALPHA-BETA-UNSATURATED ESTERS AND KETONES VIA ALDOL-ADDUCT ELIMINATION", HELVETICA CHIMICA ACTA, vol. 96, 2013, pages 1548 - 1559, XP002750967
ULLAH A. ET AL.: "COMBINATORIAL SYNTHESIS, LEAD IDENTIFICATION AND ANTITUMOR STUDY OF A CHALCONE-BASED POSITIONAL-SCANNING LIBRARY", CHEMISTRY AND BIODIVERSITY, vol. 4, 2007, pages 203 - 214, XP002750968
EDWARDS M.L. ET AL.: "CHALCONES: A NEW CLASS OF ANTIMITOTIC AGENTS", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, 1990, pages 1948 - 1954, XP002750969
DONNELLY D. ET AL.: "SYNTHESIS OF HETEROCYCLIC-SUBSTITUTED CHROMONES AND RELATED COMPOUNDS AS POTENTIAL ANTICANCER AGENTS", JOURNAL OF MEDICINAL CHEMISTRY, vol. 8, no. 6, 1965, pages 872 - 875, XP002750970
MARVEL ET AL.: "PYRIDINE ANALOGS OF CHALCONE AND THEIR POLYMERIZATION REACTIONS", JOURNAL OF ORGANIC CHEMISTRY, vol. 20, no. 12, 1955, pages 1785 - 1792, XP002742646
KOK WAI LAM ET AL.: "SYNTHESIS AND QSAR ANALYSIS OF CHALCONE DERIVATIVES AS NITRIC OXIDE INHIBITORY AGENT", MED. CHEM. RES., vol. 21, 2012, pages 1953 - 1966, XP002742648
SHINJI YAMADA ET AL.: "CATION -PI CONTROLLED SOLID-STATE PHOTODIMERIZATION OF 4-AZACHALCONES", JACS, vol. 131, 2009, pages 2098 - 2099, XP002742647
VIEWEG U A H: "Synthese neuer heterocyclisch substituierter 2-Thioxo-1,2-dihydro-pyridin-3-carbonitrile", DIE PHARMAZIE, vol. 44, no. 9, 1 January 1989 (1989-01-01), GOVI VERLAG PHARMAZEUTISCHER VERLAG GMBH, ESCHBORN, DE, pages 639 - 640, XP001526717, ISSN: 0031-7144
PATHI SUMAN ET AL.: "MICROWAVE-ASSISTED CONVENIENT SYNTHESIS OF ALPHA-BETA-UNSATURATED ESTERS AND KETONES VIA ALDOL-ADDUCT ELIMINATION", HELVETICA CHIMICA ACTA, vol. 96, 2013, pages 1548 - 1559, XP002750967
ULLAH A. ET AL.: "COMBINATORIAL SYNTHESIS, LEAD IDENTIFICATION AND ANTITUMOR STUDY OF A CHALCONE-BASED POSITIONAL-SCANNING LIBRARY", CHEMISTRY AND BIODIVERSITY, vol. 4, 2007, pages 203 - 214, XP002750968
EDWARDS M.L. ET AL.: "CHALCONES: A NEW CLASS OF ANTIMITOTIC AGENTS", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, 1990, pages 1948 - 1954, XP002750969
DONNELLY D. ET AL.: "SYNTHESIS OF HETEROCYCLIC-SUBSTITUTED CHROMONES AND RELATED COMPOUNDS AS POTENTIAL ANTICANCER AGENTS", JOURNAL OF MEDICINAL CHEMISTRY, vol. 8, no. 6, 1965, pages 872 - 875, XP002750970
Attorney, Agent or Firm:
CROOKS, Elizabeth Caroline et al. (20 Red Lion Street, London WC1R 4PJ, GB)
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