Title:
CHELATING POLYMERS AS CONTRAST AGENTS FOR MEDICAL IMAGING
Document Type and Number:
WIPO Patent Application WO1996040274
Kind Code:
A3
Abstract:
The invention provides polymeric polychelants containing polymer repeat units of formula [L-Ch-L-B] (where Ch is a polydentate chelant moiety; L is an amide or ester linkage; B is a hydrophobic group providing a carbon chain of at least 4 carbon atoms between the L linkages it interconnects) or a salt or chelate thereof, with the proviso that where Ch is 2,5-biscarboxymethyl-2,5-diazahex-1,6-diyl, the polychelant is metallated with lanthanide or manganese ions or B provides a carbon chain of at least 10 carbon atoms between the L linkages it interconnects and their salts and chelates. The paramagnetic polychelates of the polychelants of the invention have remarkably high R1 relaxivities.
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Inventors:
HOLLISTER KENNETH ROBERT
KELLER KENNETH EDMOND
WEI DONG
PENG XIN
LADD DAVID LEE
SNOW ROBERT ALLEN
KELLER KENNETH EDMOND
WEI DONG
PENG XIN
LADD DAVID LEE
SNOW ROBERT ALLEN
Application Number:
PCT/GB1996/001308
Publication Date:
February 13, 1997
Filing Date:
June 03, 1996
Export Citation:
Assignee:
NYCOMED IMAGING AS (NO)
COCKBAIN JULIAN (NO)
COCKBAIN JULIAN (NO)
International Classes:
A61K41/00; C07D255/02; A61K49/00; A61K49/08; A61K51/00; A61P39/02; C07D257/02; C07D259/00; C08G63/685; C08G69/48; (IPC1-7): A61K49/00
Domestic Patent References:
| WO1994009056A1 | 1994-04-28 | |||
| WO1990012050A1 | 1990-10-18 | |||
| WO1992008707A1 | 1992-05-29 | |||
| WO1995026754A1 | 1995-10-12 |
Foreign References:
| CS273274B1 | 1991-03-12 | |||
| EP0512661A1 | 1992-11-11 | |||
| US4707453A | 1987-11-17 |
Other References:
CHELLQUIST, ERIC M. ET AL: "Binding constant determination of WIN 22169, a novel polymeric ligand", J. PHARM. BIOMED. ANAL., VOL. 12, NO. 8, PAGE(S) 1015-22, August 1994 (1994-08-01), XP000576798
UEDA, MITSURU; HAZOME, HISASHI; IMAI, YOSHIO: "Properties of chelate polymers containing ethylenediaminetetraacetic acid structure", KOBUNSHI RONBUNSHU, 1975, VOL. 32, NO. 4, PAGES 225-8, XP000615386
UEDA, MITSURU; HAZOME, HISASHI; IMAI, YOSHIO: "Properties of chelate polymers containing ethylenediaminetetraacetic acid structure", KOBUNSHI RONBUNSHU, 1975, VOL. 32, NO. 4, PAGES 225-8, XP000615386
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