Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
CHEMICAL PARTITIONING AGENTS AND METHODS OF USING SAME
Document Type and Number:
WIPO Patent Application WO/2000/047031
Kind Code:
A2
Abstract:
The present invention is directed to partitioning agents and methods of using same to effectuate separation of a reactant, intermediate product, and/or final product from a reaction mixture while minimizing the need for traditional separation or isolation techniques.

Inventors:
WILCOX CRAIG STEPHENS (US)
YANG JAEMOON (US)
Application Number:
PCT/US2000/003523
Publication Date:
August 17, 2000
Filing Date:
February 10, 2000
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
UNIV PITTSBURGH (US)
WILCOX CRAIG STEPHENS (US)
YANG JAEMOON (US)
International Classes:
C07B63/02; C07C37/055; C07C39/21; C07C39/225; C07C43/215; C07C209/86; C07C319/28; C07C211/52; C07C323/52
Domestic Patent References:
WO2000021368A12000-04-20
Foreign References:
JPH09219310A1997-08-19
Other References:
LIN Y. ET AL.: 'Photo-asymmetric synthesis of helicenes in liquid crystals' MOL. CRYST. LIG. CRYST. SCI. TECHNOL., SECT A vol. 301, 1997, pages 267 - 282, XP002931477
SPATZ S.M.: 'Thermal decarboxylation of diaryl fumarates to stilbenes' J. ORG. CHEM. vol. 26, 1961, pages 4158 - 4161, XP002931478
See also references of EP 1165222A1
Attorney, Agent or Firm:
Miller, Raymond A. (PA, US)
Colen, Frederick H. (Smith Shaw & McClay LLP P.O. Box 488 Pittsburgh, PA, US)
Download PDF:
View/Download PDF      PDF Help
Claims:
What Is Claimed Is:
1. A compound comprised of a reactant isomer functionalized for attachment to a reactant molecule, said reactant isomer capable of being isomerized into a separating isomer, said separating isomer having a different solubility than said reactant isomer.
2. The compound of claim 1, wherein said compound has the formula wherein Rll and Rl2 are each independently the same or different, a hydrogen, a halide, OR, OH, OOH, OOR1, SRl, CN, NC, NRlR, a linear or branched alky group, an aryl group, a phenyl group, a substituted aryl, a substituted phenyl group, or other common functional group.
3. The compound of claim 1, wherein said compound has the formula wherein L is a linking group, said linking group being capable of isomerization and Rl, R2, R3, R4, R5, R6, R7, R8, R9, and RIO are, each independently, the same of different, a halide, OR, OH, OOH, OOR1, Suri, CN, NC, NRlR, a linear or branched alky group, an aryl group, a phenyl group, a substituted aryl, a substituted phenyl group, or other common functional group.
4. The compound of claim 1, said reactant isomer being a cisalkene and said separating isomer being a trans alkene.
5. The compound of claim 1, wherein said separating isomer is a geometrical isomer.
6. The compound of claim 1, wherein said separating isomer is a stereoisomer.
7. The compound of claim 1, wherein said separating isomer is a structural isomer.
8. The compound of claim 1, represented by the chemical formula:.
9. The compound of claim 1, represented by the chemical formula:.
10. The compound of claim 1, represented by the chemical formula, selected from the group consisting of :.
11. A method of separating a desired product from a reaction mixture, said method comprising: covalently linking a separating agent to a reactant; reacting said reactant molecule to form a product, said separating agent being attached to said product; isomerizing said separating agent to thereby form a separable form of said product; and separating said product from said reaction mixture.
12. The method of claim 11, further including the step of cleaving said separating agent from said product to thereby form a purified product.
13. The method of claim 11, wherein said step of isomerizing is geometrical isomerization.
14. The method of claim 11, wherein said step of isomerizing is stereoisomerization.
15. The method of claim 11, wherein said step of isomerizing is structural isomerization.
16. The method of claim 11 wherein said modified reactant molecule may be selectably transferred from one phase (e. g., hydrophobic) to another (e. g., hydrophilic) by isomerization.
17. A method of chemical synthesis comprising: attaching a soluble precipiton to a reactant to form a soluble precipitonreactant complex; reacting said soluble precipitonreactant complex with reagents and catalyst to form a soluble precipitonproduct complex; isomerizing said precipitonproduct complex to form an insoluble precipitonproduct complex; and isolating said insoluble precipitonproduct complex by filtration.
18. The method of claim 17, further including the step of cleaving said insoluble precipitonproduct complex to form a product and an insoluble precipiton.
19. The method of claim 17, wherein said insoluble precipiton is isomerized to the soluble precipiton.
20. The method of claim 17, wherein said step of attaching a soluble precipiton includes attaching a plurality of precipitons to said reactant.
21. The method of claim 20, wherein said plurality is comprised of a first precipiton and a second precipiton said first precipiton being isomerizable under different conditions than said second precipiton.
22. The method of claim 20, wherein said first precipiton is isomerizable at a first wavelength range and said second precipiton being isomerizable at a second wavelength range, said first and second wavelength range being different.
Description:
INTERNATIONALSEARCHREPORT ImationalapplicationNo. PCT/USOO/03523 BoxIObservationswherecertainclaimswerefoundunsearchable(Cont inuationofItem1offirstsheet) Thisinternationalreporthasnotbeenestablishedinrespectofcerta inclaimsunderArticle17(2)(a)forthefollowingreasons: 1.ClaimNos.: becausetheyrelatetosubjectmatternotrequiredtobesearchedbythi sAuthority,namely: 2.zClaimNos.: becausetheyrelatetopartsoftheinternationalapplicationthatdon otcomplywiththeprescribedrequirements osuch anextentthatnomeaningfulinternationalsearchcanbecarriedout,s pecifically: PleaseSeeContinuationSheet 3.0 ClaimNos.: becausetheyaredependentclaimsandarenotdraftedinaccordancewit hthesecondandthirdsentencesofRule6.4(a). BoxIIObservationswhereunityofinventionislacking(Continuation ofItem2offirstsheet) ThisInternationalSearchingAuthorityfoundmultipleinventionsin thisinternationalapplication,asfollows: PleaseSeeContinuationSheet 1.2 Asallrequiredadditionalsearchfeesweretimelypaidbytheapplican t,thisinternationalsearchreportcoversall searchableclaims. 2.Asallsearchableclaimscouldbesearchedwithouteffortjustifyin ganadditionalfee,thisAuthoritydidnotinvite paymentofanyadditionalfee. 3.F-IAsonlysomeoftherequiredadditionalsearchfeesweretimelypa idbytheapplicant,thisinternationalsearchreport coversonlythoseclaimsforwhichfeeswerepaid,specificallyclaims Nos.: 4.ENorequiredadditionalsearchfeesweretimelypaidbytheapplican t.Consequently,thisinternationalsearchreportis restrictedtotheinventionfirstmentionedintheclaims; itiscoveredbyclaimsNos.:2,4,and8-10 RemarkonProtestF-Theadditionalsearchfeeswereaccompaniedbythe applicant'sprotest. No protest accompaniedthepaymentofadditionalsearchfees. INTERNATIONALSEARCHREPORT IníernationalapplicationNo. PCT/US00103523 Continuation of Box I Reason 2: Cl-., ms 1.5,6, and 7 are unsearchable because we are offered no structural definition of any part of the compounds, as to what constitutes a reactant isomer or a separating isomer.

Claim 14 is unsearchable because the"compound"used is not structurally described in any way.

BOX Il. OBSERVATIONS WHERE UNITY OF INVENTION IS LACKING This application contains the following inventions or groups of inventions which are not so linked as to form a single general inventive concept under PCT Rule 13.1. In order for all inventions to be examined, the appropriate additional examination fees must be paid.

Group 1, claim (s) 2,4,8-10, drawn to cis olefins.

Group II, claim (s) 3, drawn to phenyl compounds linked by an isomerizable group.

Group III, claim (s) 11-13,15 and 16, drawn to a method of separation.

Group IV, claim (s) 17-22, drawn to a method of synthesis.

The inventions listed as Groups I-IV do not relate to a single general inventive concept under PCT Rule 13.1 because, under PCT Rule 13.2, they lack the same or corresponding special technical features for the following reasons: The technical feature of Group 11 appears to be the two substituted benzene rings joined by a linker. The special technical feature of Group III is a method of separating a reaction product by using any reactive isomerizable molecule. The special technical feature of Group IV is a method of performing chemical synthesis using a precipiton.

The technical feature of Group I can not be a special technical feature because examples of claimed compounds are known.

Pentachlorostilbene JP 09219310 A2 (Sumitomo Bakelite Co., Ltd.). (1997.08.19) meets the limitation of this claim. Claim 8 reads on 4- (2- [1, 1'-biphenyl]-4-ylethenyl)-phenol, which was reported in WO 2000021368. Claim 9 read on 2-methoxy-6- [2-2- (2- naphthalenyl) ethenyll-naphthalene which was reported by LIN, Y. ET AL Photoasymmetric synthesis of helicenes in liquid crystals Mol. Cryst. Liq. Cryst. Sci. Technol., Sect. A, 1997 Vol. 301 pages 267-282.

This isomerizable linker of Group 11 would include chiral sulfoxides or an asymmetric carbon atom molecules not seen in group 1.

The compounds of Group I are not required to be present in Groups III and IV. Thus, the technical feature present in Group I is not present in Groups Il-IV.

Claims 1,5,6, and 7 are unsearchable because we are offered no structural definition of any part of the compounds, as to what constitutes a reactant isomer or a separating isomer.

Claim 14 is unsearchable because the"compound"used is not structurally described in any way.




 
Previous Patent: ELECTRONIC PACKAGING SYSTEM

Next Patent: DEVICE FOR TREATING A WET MATERIAL THAT IS SPREAD ON SOIL