CHEMILUMINESCENCE SUBSTRATE HAVING HIGH LUMINESCENCE INTENSITY, LONG WAVELENGTH, AND GOOD STABILITY, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Title:

CHEMILUMINESCENCE SUBSTRATE HAVING HIGH LUMINESCENCE INTENSITY, LONG WAVELENGTH, AND GOOD STABILITY, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Document Type and Number:

WIPO Patent Application WO/2021/068828

Kind Code:

A1

Abstract:

The invention provides a chemiluminescence substrate having high luminescence intensity, a long wavelength, and good stability, and a preparation method therefor and an application thereof. The chemiluminescence substrate has a structure represented by formula I. In addition, the present invention provides an autofluorescence wavelength and intensity of a chemiluminescence probe in a physiological environment and an application of the chemiluminescence probe in living imaging. Testing results show that the chemiluminescence probe provided by the present invention has autofluorescence of a long wavelength (600 nm), is capable of effectively penetrating a skin tissue, and has high autofluorescence intensity (greater than 107 p/s/cm2/sr), excellent thermal stability (without 1,2-dioxetane structure), and diverse detection groups (applicable to different detection models).

Inventors:

GUO ZHIQIAN (CN)
ZHU WEIHONG (CN)
ZHANG YUTAO (CN)
YAN CHENXU (CN)
XU QINGSHUANG (CN)
LI JUAN (CN)
ZHANG LIAO (CN)
WANG TING (CN)
CHANG MAOJU (CN)

Application Number:

PCT/CN2020/119273

Publication Date:

April 15, 2021

Filing Date:

September 30, 2020

Export Citation:

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Assignee:

UNIV EAST CHINA SCIENCE & TECH (CN)

International Classes:

C07D209/12; C07D215/12; C07D409/14; C07F5/02; C09K11/06; G01N21/76

Domestic Patent References:

WO2018216013A1	2018-11-29
WO1990002742A1	1990-03-22

Foreign References:

CN103209970A	2013-07-17
US5981207A	1999-11-09
CN108884386A	2018-11-23