Title:
CHEMO-ENZYMATIC PROCESS FOR PROTEOME-WIDE MAPPING OF POST-TRANSLATIONAL MODIFICATION
Document Type and Number:
WIPO Patent Application WO2004056970
Kind Code:
A3
Abstract:
The invention provides a method for mapping the location of the post-translational modifications of a post-translationally modified peptide. Also provided is a solid-phase support that includes a reagent for modifying a post-translationally modified amino acid residues of a post-translationally modified, converting it into a substrate for a peptidase.
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Inventors:
SHOKAT KEVAN M (US)
KNIGHT ZACHARY (US)
KNIGHT ZACHARY (US)
Application Number:
PCT/US2003/041118
Publication Date:
March 23, 2006
Filing Date:
December 18, 2003
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
SHOKAT KEVAN M (US)
KNIGHT ZACHARY (US)
SHOKAT KEVAN M (US)
KNIGHT ZACHARY (US)
International Classes:
C07K14/47; C07K17/08; C12Q1/37; (IPC1-7): C12Q1/00
Other References:
KNIGHT ET AL: "Phosphospecific proteolysis for mapping sites of protein phosphorylation.", NATURE BIOTECH., vol. 21, no. 9, September 2003 (2003-09-01), pages 1047 - 1054, XP002993944
RUSNAK ET AL: "Identification of phosphorylated and glycosylated sites in peptide by chemically targeted proteolysis.", J BIOMOL TECHS., vol. 13, no. 4, December 2002 (2002-12-01), pages 228 - 237, XP002993945
RUSNAK ET AL: "Identification of phosphorylated and glycosylated sites in peptide by chemically targeted proteolysis.", J BIOMOL TECHS., vol. 13, no. 4, December 2002 (2002-12-01), pages 228 - 237, XP002993945
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