Title:
CHFR PROTEIN−CATALYZED POLYUBIQUITINATION OF AURORA KINASE A AND AURORA KINASE B
Document Type and Number:
WIPO Patent Application WO/2003/107002
Kind Code:
A1
Abstract:
Compositions for measuring polyubiquitination of aurora kinase A and&sol or aurora kinase B which contain aurora kinase A and&sol or aurora kinase B and chfr protein&semi and a method of screening an inhibitor or a promoter for the polyubiquitination of aurora kinase A and&sol or aurora kinase B.
Inventors:
YASUDA HIDEYO (JP)
Application Number:
PCT/JP2002/005828
Publication Date:
December 24, 2003
Filing Date:
June 12, 2002
Export Citation:
Assignee:
YASUDA HIDEYO (JP)
AXIA BIOSCIENCES INC (JP)
AXIA BIOSCIENCES INC (JP)
International Classes:
A61P35/00; C12Q1/48; G01N33/574; (IPC1-7): G01N33/50; A61K45/00; A61P35/00; G01N33/15
Domestic Patent References:
| WO2001009150A2 | 2001-02-08 |
Other References:
ARLOT-BONNEMAINS Y. ET AL.: "Identification of a functional destruction box in the xenopus lavevis aurora-A kinase pEg2", FEBS LETTERS, vol. 508, no. 1, 2001, pages 149 - 152, XP004322295
HONDA K. ET AL.: "Degradation of human aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway", ONCOGENE, vol. 19, no. 24, 2000, pages 2812 - 2819, XP002954183
WALTER A. ET AL.: "The mitotic serine/threonine kinase aurora2/AIK is regulated by phosphorylation and degradation", ONCOGENE, vol. 19, no. 42, 2000, pages 4906 - 4916, XP002954184
CHATURVEDI P. ET AL.: "Chfr regulates a mitotic stress pathway through its Ring-finger domain with ubiquitin liage activity", vol. 62, no. 6, March 2002 (2002-03-01), pages 1797 - 1801, XP002954185
KANG D. ET AL., JOURNAL OF CELL BIOLOGY, vol. 156, no. 2, January 2002 (2002-01-01), pages 249 - 259, XP002954186
HONDA K. ET AL.: "Degradation of human aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway", ONCOGENE, vol. 19, no. 24, 2000, pages 2812 - 2819, XP002954183
WALTER A. ET AL.: "The mitotic serine/threonine kinase aurora2/AIK is regulated by phosphorylation and degradation", ONCOGENE, vol. 19, no. 42, 2000, pages 4906 - 4916, XP002954184
CHATURVEDI P. ET AL.: "Chfr regulates a mitotic stress pathway through its Ring-finger domain with ubiquitin liage activity", vol. 62, no. 6, March 2002 (2002-03-01), pages 1797 - 1801, XP002954185
KANG D. ET AL., JOURNAL OF CELL BIOLOGY, vol. 156, no. 2, January 2002 (2002-01-01), pages 249 - 259, XP002954186
Attorney, Agent or Firm:
Tsukuni, Hajime (22-12 Toranomon 1-chom, Minato-ku Tokyo, JP)
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