Title:
CHIDAMIDE-CONTAINING PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/037128
Kind Code:
A1
Abstract:
Provided are a chidamide-containing pharmaceutical composition and a use thereof. The pharmaceutical composition contains chidamide and a P-glycoprotein inhibitor, and the reasonable use of the two can improve the bioavailability of chidamide and the efficacy of chidamide. The combined use of chidamide and the P-glycoprotein inhibitor with an immune checkpoint inhibitor can further effectively improve the anti-tumor efficacy of chidamide.
Inventors:
LU XIANPING (CN)
SHAN SONG (CN)
XIN LIJUN (CN)
ZHANG YU (CN)
WANG SHIGANG (CN)
DENG ZHOU (CN)
PAN DESI (CN)
YU JINDI (CN)
SHAN SONG (CN)
XIN LIJUN (CN)
ZHANG YU (CN)
WANG SHIGANG (CN)
DENG ZHOU (CN)
PAN DESI (CN)
YU JINDI (CN)
Application Number:
PCT/CN2020/111669
Publication Date:
March 04, 2021
Filing Date:
August 27, 2020
Export Citation:
Assignee:
SHENZHEN CHIPSCREEN BIOSCIENCES CO LTD (CN)
International Classes:
A61K31/4406; A61K38/15; A61K39/395; A61K45/06; A61P35/00
Domestic Patent References:
| WO2018013962A1 | 2018-01-18 |
Foreign References:
| CN101836989A | 2010-09-22 | |||
| CN109562177A | 2019-04-02 |
Other References:
LIU NIAN; GENG XIAOPING; XIONG MAOMING: "Research progress of P-glycoprotein inhibitors", FOREIGN MEDICAL SCIENCES (SECTION OF PHARMACY), vol. 33, no. 2, 30 April 2006 (2006-04-30), pages 10 - 110, XP009526481, ISSN: 1001-0971, DOI: 10.13220/j.cnki.jipr.2006.02.010
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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