CHIMERA OF BONE MORPHOGENIC PROTEIN 2 AND THE MÜLLERIAN-INHIBITING SUBSTANCE TYPE II RECEPTOR BINDING REGION OF MULLERIAN-INHIBITING SUBSTANCE

Title:

CHIMERA OF BONE MORPHOGENIC PROTEIN 2 AND THE MÜLLERIAN-INHIBITING SUBSTANCE TYPE II RECEPTOR BINDING REGION OF MULLERIAN-INHIBITING SUBSTANCE

Document Type and Number:

WIPO Patent Application WO/2018/148649

Kind Code:

A8

Abstract:

Recombinant proteins that comprise a bone morphogenic protein 2 backbone onto which was grafted a Müllerian-inhibiting substance type II receptor binding region of the Müllerian- inhibiting substance protein are provided. These proteins bind to this receptor on the surface of epithelial cancer cells, and induce apoptosis of such cells. These proteins are useful, for example, in the treatment of cancers such as ovarian, uterine, endometrial, fallopian tube, breast, prostate, and lung cancers.

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Inventors:

DUNBRACK ROLAND (US)
ADOLF-BRYFOGLE JARED (US)
ADAMS GREGORY (US)
ROBINSON MATTHEW (US)

Application Number:

PCT/US2018/017799

Publication Date:

July 30, 2020

Filing Date:

February 12, 2018

Export Citation:

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Assignee:

THE INSTITUTE FOR CANCER RES D/B/A (US)
RABD BIOTECH LLC (US)

International Classes:

A61K38/00; C07K14/435; C07K14/47; C07K14/71; C07K19/00

Attorney, Agent or Firm:

NETTER, Robert, C., Jr. et al. (US)

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