Title:
CHIMERIC ADENOVIRUSES FOR USE IN CANCER TREATMENT
Document Type and Number:
WIPO Patent Application WO2005118825
Kind Code:
A3
Abstract:
The present invention relates to oncolytic adenoviruses having therapeutic applications. Recombinant chimeric adenoviruses, and methods to produce them are provided. The chimeric adenoviruses of the invention comprise nucleic acid sequences derived from adenoviral serotypes classified within the subgroups B through F and demonstrate an enhanced therapeutic index.
Inventors:
HARDEN PAUL (US)
HERMISTON TERRY (US)
KUHN IRENE (US)
HERMISTON TERRY (US)
KUHN IRENE (US)
Application Number:
PCT/US2005/018301
Publication Date:
November 23, 2006
Filing Date:
May 24, 2005
Export Citation:
Assignee:
SCHERING AG (DE)
HARDEN PAUL (US)
HERMISTON TERRY (US)
KUHN IRENE (US)
HARDEN PAUL (US)
HERMISTON TERRY (US)
KUHN IRENE (US)
International Classes:
C12N15/861; A61K35/76; A61K48/00; C12N7/00; C12N7/01; C12N7/02
Other References:
KUHN ET AL: "319. ColoAd1, a Chimeric Ad11p/Ad3 Oncolytic Virus for the Treatment of Colon Cancer", MOLECULAR THERAPY, ACADEMIC PRESS, SAN DIEGO, CA,, US, vol. 11, 15 August 2005 (2005-08-15), pages 124, XP005015658, ISSN: 1525-0016
STONE D ET AL: "THE COMPLETE NUCLEOTIDE SEQUENCE, GENOME ORGANIZATION, AND ORIGIN OF HUMAN ADENOVIRUS TYPE 11", VIROLOGY, RAVEN PRESS, NEW YORK, NY, US, vol. 309, no. 1, 25 April 2003 (2003-04-25), pages 152 - 165, XP001153788, ISSN: 0042-6822
MEI Y-F ET AL: "Comparative analysis of the genome organization of human adenovirus 11, a member of the human adenovirus species B, and the commonly used human adenovirus 5 vector, a member of species C", JOURNAL OF GENERAL VIROLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, SPENCERS WOOD, GB, vol. 84, no. PART 8, August 2003 (2003-08-01), pages 2061 - 2071, XP002249517, ISSN: 0022-1317
YAN WEN ET AL: "Developing novel oncolytic adenoviruses through bioselection.", JOURNAL OF VIROLOGY, vol. 77, no. 4, February 2003 (2003-02-01), pages 2640 - 2650, XP002394479, ISSN: 0022-538X
HERMISTON T W ET AL: "Armed therapeutic viruses: Strategies and challenges to arming oncolytic viruses with therapeutic genes", CANCER GENE THERAPY 01 DEC 2002 UNITED STATES, vol. 9, no. 12, 1 December 2002 (2002-12-01), pages 1022 - 1035, XP002384972, ISSN: 0929-1903
HERMISTON T ET AL: "The discovery and development of selectively replicating adenoviruses as anticancer agents", TUMOR TARGETING 1999 UNITED KINGDOM, vol. 4, no. 4, 1999, pages 218 - 224, XP009070596, ISSN: 1351-8488
STONE D ET AL: "THE COMPLETE NUCLEOTIDE SEQUENCE, GENOME ORGANIZATION, AND ORIGIN OF HUMAN ADENOVIRUS TYPE 11", VIROLOGY, RAVEN PRESS, NEW YORK, NY, US, vol. 309, no. 1, 25 April 2003 (2003-04-25), pages 152 - 165, XP001153788, ISSN: 0042-6822
MEI Y-F ET AL: "Comparative analysis of the genome organization of human adenovirus 11, a member of the human adenovirus species B, and the commonly used human adenovirus 5 vector, a member of species C", JOURNAL OF GENERAL VIROLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, SPENCERS WOOD, GB, vol. 84, no. PART 8, August 2003 (2003-08-01), pages 2061 - 2071, XP002249517, ISSN: 0022-1317
YAN WEN ET AL: "Developing novel oncolytic adenoviruses through bioselection.", JOURNAL OF VIROLOGY, vol. 77, no. 4, February 2003 (2003-02-01), pages 2640 - 2650, XP002394479, ISSN: 0022-538X
HERMISTON T W ET AL: "Armed therapeutic viruses: Strategies and challenges to arming oncolytic viruses with therapeutic genes", CANCER GENE THERAPY 01 DEC 2002 UNITED STATES, vol. 9, no. 12, 1 December 2002 (2002-12-01), pages 1022 - 1035, XP002384972, ISSN: 0929-1903
HERMISTON T ET AL: "The discovery and development of selectively replicating adenoviruses as anticancer agents", TUMOR TARGETING 1999 UNITED KINGDOM, vol. 4, no. 4, 1999, pages 218 - 224, XP009070596, ISSN: 1351-8488
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