Title:
CHIMERIC ANIMAL AND METHOD FOR CONSTRUCTING THE SAME
Document Type and Number:
WIPO Patent Application WO/1997/007671
Kind Code:
A1
Abstract:
A method for constructing a chimeric nonhuman animal which comprises preparing microcells containing one or more foreign chromosomes or fragments of the same, and transferring the foreign chromosome(s) or fragments of the same into cells having differentiative pluripotency via the fusion with the microcells; a chimeric nonhuman animal which can be constructed by the above method and offsprings of the same; tissues and cells originating in the same; a method for utilizing the tissues and cells; cells which contain one or more foreign chromosomes or fragments of the same and sustain differentiative pluripotency; a method for constructing the cells; and a method for utilizing the cells.
Inventors:
TOMIZUKA KAZUMA (JP)
YOSHIDA HITOSHI (JP)
HANAOKA KAZUNORI (JP)
OSHIMURA MITSUO (JP)
ISHIDA ISAO (JP)
YOSHIDA HITOSHI (JP)
HANAOKA KAZUNORI (JP)
OSHIMURA MITSUO (JP)
ISHIDA ISAO (JP)
Application Number:
PCT/JP1996/002427
Publication Date:
March 06, 1997
Filing Date:
August 29, 1996
Export Citation:
Assignee:
KIRIN BREWERY (JP)
TOMIZUKA KAZUMA (JP)
YOSHIDA HITOSHI (JP)
HANAOKA KAZUNORI (JP)
OSHIMURA MITSUO (JP)
ISHIDA ISAO (JP)
TOMIZUKA KAZUMA (JP)
YOSHIDA HITOSHI (JP)
HANAOKA KAZUNORI (JP)
OSHIMURA MITSUO (JP)
ISHIDA ISAO (JP)
International Classes:
A01K67/027; C07K16/00; C07K16/18; C12N15/85; C12N15/90; (IPC1-7): A01K67/027; C12N5/16; C12P21/08
Other References:
TED K. CHOI et al., NATURE GENETICS, Vol. 4, p. 117-123 (1993).
I. JEAN McGOWAN-JORDAN et al., CANCER RES., Vol. 54, p. 2568-2572 (1994).
P.J. SAXON et al., EMBO J., Vol. 5, No. 13, p. 3461-3466 (1986).
M. KOI et al., JPN. J. CANCER RES., Vol. 80, p. 413-418 (1989).
I. JEAN McGOWAN-JORDAN et al., CANCER RES., Vol. 54, p. 2568-2572 (1994).
P.J. SAXON et al., EMBO J., Vol. 5, No. 13, p. 3461-3466 (1986).
M. KOI et al., JPN. J. CANCER RES., Vol. 80, p. 413-418 (1989).
Download PDF: