Title:
CHIMERIC ANTIGEN RECEPTOR CONTAINING CLDN18.2 SINGLE DOMAIN ANTIBODY AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/226836
Kind Code:
A1
Abstract:
A chimeric antigen receptor containing a CLDN18.2 single domain antibody and an application thereof. The constructed chimeric antigen receptor is good in specificity, higher in safety in vivo use, and smaller in toxicity, and can provide a treatment solution for patients who suffer from advanced gastric cancer caused by high expression of a CLDN18.2 protein and currently undergo radiotherapy, chemotherapy, and surgery treatments.
Inventors:
LI YANTAO (CN)
ZHONG YUNPENG (CN)
HAO RUIDONG (CN)
ZHONG YUNPENG (CN)
HAO RUIDONG (CN)
Application Number:
PCT/CN2023/094648
Publication Date:
November 30, 2023
Filing Date:
May 17, 2023
Export Citation:
Assignee:
SUZHOU IMMUNOHEAD BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07K16/28; C07K19/00; C12N15/13; G01N33/68
Domestic Patent References:
| WO2022100590A1 | 2022-05-19 | |||
| WO2019242505A1 | 2019-12-26 |
Foreign References:
| CN111978403A | 2020-11-24 | |||
| CN109311999A | 2019-02-05 | |||
| CN112912396A | 2021-06-04 | |||
| CN111434692A | 2020-07-21 |
Attorney, Agent or Firm:
ZHONGLUN LAW FIRM (CN)
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