CHIMERIC ANTIGEN RECEPTOR FOR RECOGNIZING FC FRAGMENT AND APPLICATION THEREOF

WIPO Patent Application WO/2022/032864

A1

A chimeric antigen receptor for recognizing an Fc fragment and an application thereof. The chimeric antigen receptor comprises an antigen binding domain, a transmembrane domain, and an intracellular costimulatory signal transduction domain. The antigen binding domain comprises an Fcγ receptor extracellular domain. According to the present invention, the Fcγ receptor extracellular domain is used as the antigen binding domain of the chimeric antigen receptor, so that the prepared CAR-T cell can recognize the Fc fragment of an antibody, and achieve, when used in combination with a tumor therapeutic antibody containing an IgG1 or IgG3 Fc fragment, an ADCC effect similar to that of natural immune cells such as NK cells; even in the case that antigen loss occurs in tumor cells, the CAR-T can also be used in combination with an antibody for recognizing another target to achieve an efficient killing effect on the tumor cells.

JP6800219	Specific interleukin-15 (IL-15) antagonist polypeptides and their use for the treatment of inflammatory and autoimmune diseases
WO/2005/071069	CHIMERIC EMPTY CAPSIDS OF THE INFECTIOUS BURSAL DISEASE VIRUS (IBDV), OBTAINMENT PROCESS AND APPLICATIONS
WO/1999/043713	ENHANCING THE CIRCULATING HALF-LIFE OF ANTIBODY-BASED FUSION PROTEINS

LI PENG (CN)
CUI YUANBIN (CN)
TANG CHAOYANG (CN)
LI SHANGLIN (CN)
YAO YAO (CN)
LIN SIMIAO (CN)

PCT/CN2020/122310

February 17, 2022

October 21, 2020

Click for automatic bibliography generation  

SHENZHEN IN VIVO BIOMEDICINE TECH LIMITED COMPANY (CN)

C07K19/00; A61K35/17; A61K38/17; A61P35/00; C12N5/0783; C12N5/10; C12N15/867

CN110204619B	2020-06-05
CN110684739A	2020-01-14
CN111349178A	2020-06-30
CN110616191A	2019-12-27

BEYOND ATTORNEYS AT LAW (CN)

View/Download PDF      PDF Help

Previous Patent: DISPLAY PANEL AND DISPLAY DEVICE

Next Patent: TRAFFIC DESCRIPTOR TRANSMISSION METHOD AND RELATED DEVICE