Title:
CHIMERIC ANTIGEN RECEPTOR TARGETING NK ACTIVATED RECEPTOR
Document Type and Number:
WIPO Patent Application WO/2022/048523
Kind Code:
A1
Abstract:
The present invention relates to a novel chimeric antigen receptor targeting an NK activated receptor. The chimeric antigen receptor can be used to treat malignant tumors caused by NK cytopathy, and can also prevent NK cells in a patient from killing introduced therapeutic CAR cells under the background of universal CAR cells. The present invention also relates to an engineered immune cell expressing the novel chimeric antigen receptor, a composition containing same, and the use thereof in the treatment of diseases.
Inventors:
ZHOU YALI (CN)
CHEN GONG (CN)
JIANG XIAOYAN (CN)
REN JIANGTAO (CN)
HE XIAOHONG (CN)
WANG YANBIN (CN)
HAN LU (CN)
CHEN GONG (CN)
JIANG XIAOYAN (CN)
REN JIANGTAO (CN)
HE XIAOHONG (CN)
WANG YANBIN (CN)
HAN LU (CN)
Application Number:
PCT/CN2021/115495
Publication Date:
March 10, 2022
Filing Date:
August 31, 2021
Export Citation:
Assignee:
NANJING BIOHENG BIOTECH CO LTD (CN)
International Classes:
C07K19/00; A61K35/17; A61K39/00; A61P31/00; A61P33/00; A61P35/00; A61P37/02; C12N5/10; C12N15/62; C12N15/867
Domestic Patent References:
| WO2011109400A2 | 2011-09-09 |
Foreign References:
| CN112029001A | 2020-12-04 | |||
| CN111363046A | 2020-07-03 | |||
| US20110150870A1 | 2011-06-23 | |||
| CN110944661A | 2020-03-31 | |||
| CN111065649A | 2020-04-24 |
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY LTD. (CN)
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