Title:
CHIMERIC ANTIGEN RECEPTOR THAT RECOGNIZES CCR8 AS ANTIGEN
Document Type and Number:
WIPO Patent Application WO/2022/211046
Kind Code:
A1
Abstract:
This chimeric antigen receptor that recognizes CCR8 as an antigen has a cyctotoxic activity against CCR8-expressing cells by being expressed by effector cells.
Inventors:
YOSHIDA TETSUYA (JP)
YOSHIKAWA MAI (JP)
HARUNA MIYA (JP)
NAGIRA MORIO (JP)
TAKAHASHI KOJI (JP)
HAYASHIDA MARINA (JP)
MIWA HIROTO (JP)
SONODA YUDAI (JP)
OHKURA NAGANARI (JP)
SAKAGUCHI SHIMON (JP)
WADA HISASHI (JP)
YOSHIKAWA MAI (JP)
HARUNA MIYA (JP)
NAGIRA MORIO (JP)
TAKAHASHI KOJI (JP)
HAYASHIDA MARINA (JP)
MIWA HIROTO (JP)
SONODA YUDAI (JP)
OHKURA NAGANARI (JP)
SAKAGUCHI SHIMON (JP)
WADA HISASHI (JP)
Application Number:
PCT/JP2022/016625
Publication Date:
October 06, 2022
Filing Date:
March 31, 2022
Export Citation:
Assignee:
SHIONOGI & CO (JP)
UNIV OSAKA (JP)
UNIV OSAKA (JP)
International Classes:
C12N15/62; A61K35/17; A61P35/00; C07K14/725; C07K16/28; C07K19/00; C12N5/10; C12N15/12; C12N15/13; C12N15/63
Domestic Patent References:
| WO2020138489A1 | 2020-07-02 | |||
| WO2018181425A1 | 2018-10-04 | |||
| WO2018112032A1 | 2018-06-21 | |||
| WO2020138489A1 | 2020-07-02 | |||
| WO2021142002A1 | 2021-07-15 | |||
| WO2021152186A2 | 2021-08-05 | |||
| WO2021163064A2 | 2021-08-19 | |||
| WO2021178749A2 | 2021-09-10 | |||
| WO2021194942A1 | 2021-09-30 | |||
| WO2021260208A2 | 2021-12-30 | |||
| WO2021260209A2 | 2021-12-30 | |||
| WO2021260210A2 | 2021-12-30 |
Foreign References:
| JP2019536469A | 2019-12-19 | |||
| US20190092875A1 | 2019-03-28 | |||
| US10087259B1 | 2018-10-02 |
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SAIBIL S.D., OHASHI P.S.: "Targeting T Cell Activation in Immuno-Oncology", CURRENT ONCOLOGY, MULTIMED INC, vol. 27, no. 12, 1 April 2020 (2020-04-01), pages 98 - 105, XP055972255, DOI: 10.3747/co.27.5285
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J. BIOL. CHEM., vol. 272, no. 28, 1997, pages 17251 - 4
CANCER RES., vol. 76, no. 4, 2016, pages 04 - 11
IMMUNITY, vol. 45, 2016, pages 1135 - 1147
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DANIEL O VILLARREAL ET AL., ASCO, 2018, Retrieved from the Internet
CANCER RES., vol. 78, no. 18, 2018, pages 5340 - 5348
PROC. NATL. ACAD. SCI. USA, vol. 90, no. 2, 1993, pages 720 - 724
CELL RES., vol. 27, 2017, pages 38 - 58
CELL STEM CELL, vol. 23, no. 2, 2018, pages 181 - 192
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"Current Protocols Essential Laboratory Techniques", CURRENT PROTOCOLS, 2012
"GenBank", Database accession no. AAI 26243.1
SATO, K ET AL., CANCER RES., vol. 53, 1993, pages 851
CANCER SCIENCE, vol. 111, 2020, pages 1478 - 1490
MOL. THER. NUCLEIC ACIDS, vol. 12, 2018, pages 793 - 804
SAIBIL S.D., OHASHI P.S.: "Targeting T Cell Activation in Immuno-Oncology", CURRENT ONCOLOGY, MULTIMED INC, vol. 27, no. 12, 1 April 2020 (2020-04-01), pages 98 - 105, XP055972255, DOI: 10.3747/co.27.5285
NAT. REV. IMMUNOL., vol. 6, no. 4, 2006, pages 295 - 307
EUR. J. IMMUNOL., vol. 40, 2010, pages 3325 - 3335
J. CLIN. ONCOL., vol. 24, 2006, pages 5373 - 5380
NAT. MED., vol. 10, 2004, pages 942 - 949
J. CLIN. ONCOL., vol. 25, 2007, pages 2586 - 2593
CANCER, vol. 107, 2006, pages 2866 - 2872
EUR. J. CANCER, vol. 44, 2008, pages 1875 - 1882
CELL. MOL. IMMUNOL., vol. 8, 2011, pages 59 - 66
J. IMMUNOL., vol. 157, no. 7, 1996, pages 2759 - 63
J. BIOL. CHEM., vol. 272, no. 28, 1997, pages 17251 - 4
CANCER RES., vol. 76, no. 4, 2016, pages 04 - 11
IMMUNITY, vol. 45, 2016, pages 1135 - 1147
PROC. NATL. ACAD. SCI. USA, vol. 115, no. 45, 2018, pages 10672 - 10681
DANIEL O VILLARREAL ET AL., ASCO, 2018, Retrieved from the Internet
CANCER RES., vol. 78, no. 18, 2018, pages 5340 - 5348
PROC. NATL. ACAD. SCI. USA, vol. 90, no. 2, 1993, pages 720 - 724
CELL RES., vol. 27, 2017, pages 38 - 58
CELL STEM CELL, vol. 23, no. 2, 2018, pages 181 - 192
J. HEMATOL. ONCOL., vol. 12, no. 1, 2019, pages 49
"Current Protocols Essential Laboratory Techniques", CURRENT PROTOCOLS, 2012
"GenBank", Database accession no. AAI 26243.1
SATO, K ET AL., CANCER RES., vol. 53, 1993, pages 851
CANCER SCIENCE, vol. 111, 2020, pages 1478 - 1490
MOL. THER. NUCLEIC ACIDS, vol. 12, 2018, pages 793 - 804
Attorney, Agent or Firm:
SUGITA Ken-ichi et al. (JP)
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