Title:
CHIMERIC ANTIGEN RECEPTORS BINDING NECTIN-4
Document Type and Number:
WIPO Patent Application WO/2024/059733
Kind Code:
A3
Abstract:
Chimeric antigen receptors (CAR) with a binding domain that binds Nectin-4 are disclosed. The Nectin-4 binding domain can be derived from the murine antibody M22-321b41.1. The CAR disclosed herein can be expressed by an immune cell to be used in the treatment of Nectin-4-expressing cancers, such as bladder, breast, ovarian, esophageal, lung, colorectal, or pancreatic cancers.
Inventors:
LEE JOHN K (US)
WU LI-TING (US)
WU LI-TING (US)
Application Number:
PCT/US2023/074229
Publication Date:
May 02, 2024
Filing Date:
September 14, 2023
Export Citation:
Assignee:
FRED HUTCHINSON CANCER CENTER (US)
International Classes:
C07K14/705; A61K45/06; A61P37/02; C07K16/28; C12N15/85
Attorney, Agent or Firm:
WINGER, C. Rachal et al. (US)
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