Title:
CHIMERIC COMPOUND USED FOR TARGETED DEGRADATION OF BCL-2 PROTEIN, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/067818
Kind Code:
A1
Abstract:
The present disclosure relates to a chimeric compound used for targeted degradation of a BCL-2 protein, a preparation method therefor, and pharmaceutical application thereof. Specifically, the present disclosure relates to a heterocyclic compound represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the heterocyclic compound, and use thereof as a therapeutic agent, particularly use as a BCL-2 degradation agent and use in the preparation of a medicament for treating and/or preventing a BCL-2-mediated or dependent disease or condition.
Inventors:
DONG PING (CN)
LI XIN (CN)
SHU CHUNFENG (CN)
ZHANG JING (CN)
WANG HAOWEI (CN)
HE FENG (CN)
LI XIN (CN)
SHU CHUNFENG (CN)
ZHANG JING (CN)
WANG HAOWEI (CN)
HE FENG (CN)
Application Number:
PCT/CN2023/122662
Publication Date:
April 04, 2024
Filing Date:
September 28, 2023
Export Citation:
Assignee:
JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D401/12; A61K31/4427; A61K31/4523; A61P35/00; A61P35/02; C07D401/14; C07D403/12; C07D403/14; C07D413/12; C07D413/14; C07D417/12; C07D417/14
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
Download PDF: