Title:
CHIMERIC ENDOLYSIN LYS109 WHICH EFFECTIVELY CONTROLS STAPHYLOCOCCUS AUREUS
Document Type and Number:
WIPO Patent Application WO/2020/256268
Kind Code:
A1
Abstract:
The present invention relates to chimeric endolysin Lys109 which effectively controls Staphylococcus aureus, wherein the endolysin Lys109 of the present invention has a novel amino acid sequence that has not been conventionally studied. Endolysin Lys109 of the present invention can be used as a biological regulator capable of effectively inhibiting a wide range of Staphylococcus aureus and a biofilm produced thereby. In addition, endolysin Lys109 can kill Staphylococcus aureus without regard for resistance to conventional antibiotics, and thus can be widely used for treatment of diseases caused by Staphylococcus aureus infection. Moreover, endolysin Lys109 can also be used to resolve medical problems caused by Staphylococcus aureus which has antibiotic resistance.
Inventors:
RYU SANG YEOL (KR)
SON BO KYUNG (KR)
SON BO KYUNG (KR)
Application Number:
PCT/KR2020/005243
Publication Date:
December 24, 2020
Filing Date:
April 21, 2020
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
C12N9/36; A23K20/189; A23L33/18; A61K38/00; A61P31/04; C11D3/386
Foreign References:
| KR20170087770A | 2017-07-31 | |||
| KR101785487B1 | 2017-10-16 | |||
| KR101200333B1 | 2012-11-12 | |||
| KR102097128B1 | 2020-04-06 |
Other References:
HAMED HADDAD KASHANI, FAHIMI HOSSEIN, DASTEH GOLI YASAMAN, MONIRI REZVAN: "A Novel Chimeric Endolysin with Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus", FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, vol. 7, XP055767248, DOI: 10.3389/fcimb.2017.00290
Attorney, Agent or Firm:
TAEDONG INTERNATIONAL PATENT LAW&FIRM (KR)
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