Title:
CHIMERIC NEUTRALIZING ANTIBODY AND PRODUCTION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/105811
Kind Code:
A1
Abstract:
Provided are a neutralizing antibody having high neutralizing activity against a virus and a production method thereof. A chimeric antibody of neutralizing antibodies against a virus, said chimeric antibody comprising a heavy chain cloned from a memory B cell or plasma cell encoding an antibody specific to the virus and a light chain cloned from another memory B cell or plasma cell encoding another antibody specific to the aforesaid virus, characterized by being obtained by an antibody-producing cell to which an arbitrary combination of multiple types of the heavy chains with multiple types of the light chains has been introduced.
Inventors:
AKAZAWA CHIHIRO (JP)
HISAMATSU DAISUKE (JP)
HISAMATSU DAISUKE (JP)
Application Number:
PCT/JP2022/016534
Publication Date:
June 15, 2023
Filing Date:
March 31, 2022
Export Citation:
Assignee:
JUNTENDO EDUCATIONAL FOUND (JP)
International Classes:
C07K16/46; A61K39/395; A61P31/14; C12N15/13; C12P21/08
Other References:
XIE JIAJIA, DING CHENGCHAO, HE JUN, ZHANG YUQING, NI SHUANGSHUANG, ZHANG XIANGYU, CHEN QINGQING, WANG JING, HUANG LINA, HE HONGLIA: "Novel Monoclonal Antibodies and Recombined Antibodies Against Variant SARS-CoV-2", FRONTIERS IN IMMUNOLOGY, FRONTIERS MEDIA, LAUSANNE, CH, vol. 12, 30 August 2021 (2021-08-30), Lausanne, CH , XP055912188, ISSN: 1664-3224, DOI: 10.3389/fimmu.2021.715464
BAUM ALINA, FULTON BENJAMIN O., WLOGA ELZBIETA, COPIN RICHARD, PASCAL KRISTEN E., RUSSO VINCENZO, GIORDANO STEPHANIE, LANZA KATHRY: "Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 369, no. 6506, 21 August 2020 (2020-08-21), US , pages 1014 - 1018, XP093069117, ISSN: 0036-8075, DOI: 10.1126/science.abd0831
KU ZHIQIANG, XIE XUPING, DAVIDSON EDGAR, YE XIAOHUA, SU HANG, MENACHERY VINEET D., LI YIZE, YUAN ZIHAO, ZHANG XIANWEN, MURUATO ANT: "Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape", NATURE COMMUNICATIONS, 1 December 2021 (2021-12-01), XP055913116, Retrieved from the Internet [retrieved on 20220414], DOI: 10.1038/s41467-020-20789-7
BAUM ALINA, FULTON BENJAMIN O., WLOGA ELZBIETA, COPIN RICHARD, PASCAL KRISTEN E., RUSSO VINCENZO, GIORDANO STEPHANIE, LANZA KATHRY: "Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 369, no. 6506, 21 August 2020 (2020-08-21), US , pages 1014 - 1018, XP093069117, ISSN: 0036-8075, DOI: 10.1126/science.abd0831
KU ZHIQIANG, XIE XUPING, DAVIDSON EDGAR, YE XIAOHUA, SU HANG, MENACHERY VINEET D., LI YIZE, YUAN ZIHAO, ZHANG XIANWEN, MURUATO ANT: "Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape", NATURE COMMUNICATIONS, 1 December 2021 (2021-12-01), XP055913116, Retrieved from the Internet
Attorney, Agent or Firm:
ARUGA PATENT OFFICE (JP)
Download PDF:
Previous Patent: BLOCK COPOLYMER, COMPOSITION, HEAT SHRINKABLE FILM, SHEET AND SHEET MOLDED ARTICLE
Next Patent: TIRE
Next Patent: TIRE