Title:
CHIMERIC POLYPEPTIDE FOR REGULATING CELL PHYSIOLOGICAL ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2023/274303
Kind Code:
A9
Abstract:
A chimeric polypeptide, containing a binding peptide that can specifically bind to a target molecule, a receptor regulatory domain containing one or more cleavage sites, and an intracellular domain. The receptor regulatory domain comprises an extracellular region and a transmembrane region, wherein the extracellular region and the transmembrane region are not both derived from a Notch protein. The binding of the binding peptide to the target molecule can induce the cleavage of the receptor regulatory domain, thereby releasing the intracellular domain.
Inventors:
WANG YI (CN)
LI ZONGHAI (CN)
LI ZONGHAI (CN)
Application Number:
PCT/CN2022/102395
Publication Date:
May 19, 2023
Filing Date:
June 29, 2022
Export Citation:
Assignee:
CARSGEN THERAPEUTICS CO LTD (CN)
International Classes:
C07K14/705; A61K35/00; A61K38/17; C12N15/00; C12N15/12
Attorney, Agent or Firm:
BEIJING CAI HE LAW FIRM (CN)
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