Title:
CHIMERIC PROTEIN, AND IMMUNE EFFECTOR CELL EXPRESSING SAME AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/109980
Kind Code:
A1
Abstract:
Provided are an immune effector cell expressing a chimeric protein and an application thereof. The immune effector cell expresses a chimeric protein containing an extracellular domain of a TGF-β receptor and an intracellular signal domain of a receptor of an IL-2 family protein. Further provided are a pharmaceutical composition containing the immune effector cell and a use of the immune effector cell or the pharmaceutical composition for the preparation of a medicament for preventing or treating tumors or pathogenic microorganism infection. The immune effector cell expressing the chimeric protein of the present invention is capable of transforming stimulation of TGF-β into a positive signal of IL-2, IL-7, or IL-21, and inhibiting TGF-β-induced Treg differentiation, thereby promoting survival and proliferation of immune cells, and is also capable of reducing the effect of TGF-β on cell killing ability.
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Inventors:
LI ZONGHAI (CN)
WANG YI (CN)
WANG YI (CN)
Application Number:
PCT/CN2018/119588
Publication Date:
June 13, 2019
Filing Date:
December 06, 2018
Export Citation:
Assignee:
CARSGEN THERAPEUTICS CO LTD (CN)
SHANGHAI CANCER INST (CN)
SHANGHAI CANCER INST (CN)
International Classes:
C12N5/10; A61K35/17; A61P35/00
Foreign References:
| CN103582699A | 2014-02-12 | |||
| US20160361265A1 | 2016-12-15 |
Other References:
CLAUDIA PENAFUERTEL ET AL.: "B Effector Cells Activated by a Chimeric Protein Consisting of IL -2 and the Ectodomain of TGF-b Receptor II Induce Potent Antitumor Immunity", CANCER RESEARCH, vol. 72, no. 5, 12 January 2012 (2012-01-12), pages 1210 - 1220, XP055505176, ISSN: 0008-5472, doi:10.1158/0008-5472.CAN-11-1659
STEPHAN GASSER ET AL.: "Constitutive Expression of a Chimeric Receptor That Delivers IL -2/ IL -15 Signals Allows Antigen-Independent Proliferation of CD 8 + CD 44high But Not Other T Cells", THE JOURNAL OF IMMUNOLOGY, vol. 164, 20 March 2000 (2000-03-20), pages 5659 - 5667, XP002783502, ISSN: 1550-6606, DOI: doi:10.4049/jimmunol.164.11.5659
STEPHAN GASSER ET AL.: "Constitutive Expression of a Chimeric Receptor That Delivers IL -2/ IL -15 Signals Allows Antigen-Independent Proliferation of CD 8 + CD 44high But Not Other T Cells", THE JOURNAL OF IMMUNOLOGY, vol. 164, 20 March 2000 (2000-03-20), pages 5659 - 5667, XP002783502, ISSN: 1550-6606, DOI: doi:10.4049/jimmunol.164.11.5659
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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