Title:
CHIMERIC RECEPTORS WITH 4-1BB STIMULATORY SIGNALING DOMAIN
Document Type and Number:
WIPO Patent Application WO2005044996
Kind Code:
A3
Abstract:
The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use. Also included is a method for obtaining an enriched population of NK cells from a mixed population of NK cells and T cells.
Inventors:
CAMPANA DARIO (US)
IMAI CHIHAYA (US)
IMAI CHIHAYA (US)
Application Number:
PCT/US2004/037032
Publication Date:
September 09, 2005
Filing Date:
November 05, 2004
Export Citation:
Assignee:
ST JUDE CHILDRENS RES HOSPITAL (US)
CAMPANA DARIO (US)
IMAI CHIHAYA (US)
CAMPANA DARIO (US)
IMAI CHIHAYA (US)
International Classes:
A61K39/395; C07H21/04; C07K14/705; C07K14/74; C07K16/28; C07K16/44; C07K16/46; C12N; (IPC1-7): C07K16/46; A61K39/395
Other References:
IMAI C. ET AL.: "T-cell immunotherapy for B-lineage acute lymphoblastic leulcemia using chimeric antigen receptors that deliver 4-1BB-mediated constimulatory signals.", BLOOD., vol. 102, no. 11, 16 November 2003 (2003-11-16), pages 66 - 67, XP008050210
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