Title:
CHIRAL ARYL PROPIONIC ACID DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF, AND USE
Document Type and Number:
WIPO Patent Application WO/2023/202554
Kind Code:
A1
Abstract:
Disclosed are a chiral aryl propionic acid derivative and a pharmaceutical composition thereof, and a use. The chiral aryl propionic acid derivative is as shown in formula (I), and the definition of each group is given in the description. The chiral aryl propionic acid derivative has antipyretic, analgesic and anti-inflammatory effects. The compound of the present invention has high activity and can be locally administrated, a reduced dosage is expected, and adverse reactions are reduced.
More Like This:
Inventors:
MENG YUELEI (CN)
WANG LU (CN)
GAO LIANG (CN)
WANG LU (CN)
GAO LIANG (CN)
Application Number:
PCT/CN2023/088864
Publication Date:
October 26, 2023
Filing Date:
April 18, 2023
Export Citation:
Assignee:
SHIJIAZHUANG DISCOVERY MEDICINE TECH CO LTD (CN)
International Classes:
C07C219/10; A61K31/216; A61K31/22; A61K31/223; A61K31/265; A61K31/4035; A61P29/00; C07C217/08; C07C219/16; C07C229/12; C07C323/58; C07D209/48
Domestic Patent References:
| WO2014065577A1 | 2014-05-01 |
Foreign References:
| CN106661061A | 2017-05-10 | |||
| CN111635309A | 2020-09-08 |
Other References:
NARUTO SHUNJI, YORIHISA TANAKA, RYOZO HAYASHI, ATSUSUKE TERADA: "Structural determination of rat urinary metabolites of sodium 2-[4-(2-oxocyclopentylmethyl)phenyl]propionate dihydrate (loxoprofen sodium), a new antiinflammatory agent", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 32, no. 1, 25 January 1984 (1984-01-25), pages 258 - 267, XP093098137
NARUTO SHUNJI, ATSUSUKE TERADA: "Synthesis of the Eight Possible Optically Active Isomers of 2-[4-(2-Hydroxycyclopentylmethyl) phenyl] propionic Acid", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 31, no. 12, 25 December 1983 (1983-12-25), pages 4319 - 4323, XP093098190
HAI, YE ET AL.: "HR1405-01, a Safe intravenous NSAID with superior anti-inflammatory and analgesic activities in preclinical trials", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 235, no. 5, 18 March 2022 (2022-03-18), XP087022777, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2022.114258
NARUTO SHUNJI, ATSUSUKE TERADA: "Synthesis of the Eight Possible Optically Active Isomers of 2-[4-(2-Hydroxycyclopentylmethyl) phenyl] propionic Acid", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 31, no. 12, 25 December 1983 (1983-12-25), pages 4319 - 4323, XP093098190
HAI, YE ET AL.: "HR1405-01, a Safe intravenous NSAID with superior anti-inflammatory and analgesic activities in preclinical trials", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 235, no. 5, 18 March 2022 (2022-03-18), XP087022777, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2022.114258
Download PDF:
Previous Patent: METHODS OF TREATING NEUROLOGICAL DISEASES
Next Patent: EMBEDDED-REFRIGERATOR DOOR ASSEMBLY, AND INSTALLATION METHOD THEREFOR
Next Patent: EMBEDDED-REFRIGERATOR DOOR ASSEMBLY, AND INSTALLATION METHOD THEREFOR