Title:
CHIRAL IRIDIUM AQUA COMPLEX AND METHOD FOR PRODUCING OPTICALLY ACTIVE HYDROXY COMPOUND USING THE SAME
Document Type and Number:
WIPO Patent Application WO/2010/004957
Kind Code:
A1
Abstract:
Disclosed is a novel chiral iridium aqua complex having good storage stability, which can be easily produced. The chiral iridium aqua complex can achieve a high yield and a high stereoselectivity in an asymmetric transfer hydrogenation reaction. The chiral iridium aqua complex is represented by formula (1A) (wherein Ra, Rb, Rc, Rd and Re may be the same or different and each represents a hydrogen atom, a methyl group, an ethyl group or a phenyl group; R1 and R2 may be the same or different and each represents an optionally substituted aryl group, or R1 and R2 may combine together to form an optionally substituted C3-4 linear alkylene group which forms a ring; R3 represents an optionally substituted alkylsulfonyl group or an optionally substituted arylsulfonyl group; R4 represents a hydrogen atom, an optionally substituted alkylsulfonyl group or an optionally substituted arylsulfonyl group; X represents a monovalent or divalent anion; and when X is a monovalent anion, n represents 2, and when X is a divalent anion, n represents 1). A method for producing an optically active hydroxy compound using the chiral iridium aqua complex is also disclosed.
Inventors:
CARREIRA ERICK M (CH)
Application Number:
PCT/JP2009/062289
Publication Date:
January 14, 2010
Filing Date:
July 06, 2009
Export Citation:
Assignee:
SUMITOMO CHEMICAL CO (JP)
CARREIRA ERICK M (CH)
CARREIRA ERICK M (CH)
International Classes:
C07F17/02; C07B53/00; C07C29/143; C07C33/46; C07C201/12; C07C205/09; C07C205/16; C07C247/10; C07C253/30; C07C255/12; C07C255/13; C07C311/09; C07C311/18; C07D307/54; C07D333/24; C07B61/00
Foreign References:
| JPH11335385A | 1999-12-07 | |||
| JP2003502296A | 2003-01-21 | |||
| JPH11335385A | 1999-12-07 | |||
| JP2006524189A | 2006-10-26 | |||
| JP2008178040A | 2008-07-31 |
Other References:
J. AM. CHEM. SOC., vol. 118, 1996, pages 2521 - 2522
J. AM. CHEM. SOC., vol. 126, 2004, pages 3020 - 3021
SYNLLET, 2006, pages 1155 - 1160
EUR. J. INORG. CHEM., 2001, pages 1361 - 1369
J. AM. CHEM. SOC., vol. 129, 2007, pages 8976 - 8977
ORGANOMETALLICS, vol. 18, 1999, pages 5470 - 5474
CHEM. COMMUN., 2001, pages 2572 - 2573
J. ORG. CHEM., vol. 69, 2004, pages 5187 - 5195
ORGANOMETALLICS, vol. 18, 1999, pages 5470
See also references of EP 2311846A4
J. AM. CHEM. SOC., vol. 126, 2004, pages 3020 - 3021
SYNLLET, 2006, pages 1155 - 1160
EUR. J. INORG. CHEM., 2001, pages 1361 - 1369
J. AM. CHEM. SOC., vol. 129, 2007, pages 8976 - 8977
ORGANOMETALLICS, vol. 18, 1999, pages 5470 - 5474
CHEM. COMMUN., 2001, pages 2572 - 2573
J. ORG. CHEM., vol. 69, 2004, pages 5187 - 5195
ORGANOMETALLICS, vol. 18, 1999, pages 5470
See also references of EP 2311846A4
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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