Title:
Chiral TACN/NOTA compounds/derivatives with and without metals for application
Document Type and Number:
WIPO Patent Application WO/2022/194298
Kind Code:
A1
Abstract:
Cyclic 1, 4, 7-triazacyclononane-1, 4, 7-triacetic acid chelators and metal complexes comprising the same useful as positron emission tomography imaging agents, magnetic resonance imaging contrast agents, and computed tomography imaging agents, and optical imaging agents, and methods of use and preparation thereof.
Inventors:
LAW GA-LAI (CN)
Application Number:
PCT/CN2022/081959
Publication Date:
September 22, 2022
Filing Date:
March 21, 2022
Export Citation:
Assignee:
UNIV HONG KONG POLYTECHNIC (CN)
International Classes:
C07D255/02; A61K49/10; C07F5/00
Domestic Patent References:
| WO2018134430A1 | 2018-07-26 | |||
| WO2021016392A1 | 2021-01-28 | |||
| WO2009124764A1 | 2009-10-15 | |||
| WO1997001360A2 | 1997-01-16 | |||
| WO2014122432A1 | 2014-08-14 | |||
| WO2005021538A1 | 2005-03-10 | |||
| WO2019246445A1 | 2019-12-26 |
Foreign References:
| CN112062695A | 2020-12-11 | |||
| US20090270600A1 | 2009-10-29 | |||
| US20100092396A1 | 2010-04-15 | |||
| US20140336373A1 | 2014-11-13 |
Other References:
FARRUGIA L.J., ET AL.: "SYNTHESIS, X-RAY CRYSTAL STRUCTURE AND SPECTROSCOPY OF THE HYDROGEN-BRIDGED DIMER ¬CR III(L.H3L)CR III¾¬PF6¾3 (H3L = N,N',N''-TRIS¬(2S)-2-HYDROXYPROPYL¾-1,4,7-TRIAZACYCLONONANE).", POLYHEDRON, PERGAMON PRESS, OXFORD., GB, vol. 14., no. 04., 1 January 1995 (1995-01-01), GB , pages 541 - 545., XP000914259, ISSN: 0277-5387, DOI: 10.1016/0277-5387(94)00265-G
MAKRIS GEORGE, SHEGANI ANTONIO, KANKANAMALAGE PAVITHRA H. A., KUCHUK MARINA, BANDARI RAJENDRA P., SMITH CHARLES J., HENNKENS HEATH: "Preclinical Evaluation of Novel 64 Cu-Labeled Gastrin-Releasing Peptide Receptor Bioconjugates for PET Imaging of Prostate Cancer", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 32, no. 7, 21 July 2021 (2021-07-21), US , pages 1290 - 1297, XP055967903, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.0c00656
NONAT ALINE M., CHRISTELLE GATEAU,PASCAL H. FRIES,LOTHAR HELM,MARINELLA MAZZANTI: "New Bisaqua Picolinate-Based Gadolinium Complexes as MRI Contrast Agents with Substantial High-Field Relaxivities", EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, vol. 2012, no. 12, 31 December 2012 (2012-12-31), pages 2049 - 2061, XP055967898, DOI: 10.1002/ejic.201101162
MAKRIS GEORGE, SHEGANI ANTONIO, KANKANAMALAGE PAVITHRA H. A., KUCHUK MARINA, BANDARI RAJENDRA P., SMITH CHARLES J., HENNKENS HEATH: "Preclinical Evaluation of Novel 64 Cu-Labeled Gastrin-Releasing Peptide Receptor Bioconjugates for PET Imaging of Prostate Cancer", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 32, no. 7, 21 July 2021 (2021-07-21), US , pages 1290 - 1297, XP055967903, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.0c00656
NONAT ALINE M., CHRISTELLE GATEAU,PASCAL H. FRIES,LOTHAR HELM,MARINELLA MAZZANTI: "New Bisaqua Picolinate-Based Gadolinium Complexes as MRI Contrast Agents with Substantial High-Field Relaxivities", EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, vol. 2012, no. 12, 31 December 2012 (2012-12-31), pages 2049 - 2061, XP055967898, DOI: 10.1002/ejic.201101162
Attorney, Agent or Firm:
BEIJING PAT SF INTELLECTUAL PROPERTY AGENCY CO. LTD (CN)
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