Title:
CHOLANIC ACID COMPOUND FOR PREVENTING OR TREATING FXR-MEDIATED DISEASES
Document Type and Number:
WIPO Patent Application WO/2017/152677
Kind Code:
A1
Abstract:
The present invention relates to a cholanic acid compound for preventing or treating FXR-mediated diseases. Specifically, disclosed are a cholanic acid compound represented by formula (I) and a pharmaceutical composition containing the compound, or a crystalline form, a pharmaceutically-acceptable salt, a prodrug, a tautomer, a stereoisomer, an enantiomer, and a hydrate or a solvate thereof. The compound in the present invention can be used as a farnesol X receptor agonist and can therefore be applied to the preparation of drugs for treating FXR-related diseases (for example, fatty liver).
Inventors:
WANG YIHAN (CN)
RE XINGYE (CN)
RE XINGYE (CN)
Application Number:
PCT/CN2016/109851
Publication Date:
September 14, 2017
Filing Date:
December 14, 2016
Export Citation:
Assignee:
SHENZHEN TARGETRX INC (CN)
International Classes:
C07J9/00; A61K31/575; A61P1/00; A61P1/16; A61P3/00; A61P3/10; A61P9/00; A61P13/12; A61P35/00; C07B59/00
Domestic Patent References:
| WO2015061421A1 | 2015-04-30 | |||
| WO2002072598A1 | 2002-09-19 |
Foreign References:
| CN106008639A | 2016-10-12 |
Other References:
MOLECULAR NUCLEAR MEDICINE, 31 May 2001 (2001-05-31), pages 389
JIANG, WENFENG ET AL.: "Application of Deuteration in Drug Research", QILU PHARMACEUTICAL AFFAIRS, vol. 29, no. 11, 31 December 2010 (2010-12-31), pages 682, XP008173943
JIANG, WENFENG ET AL.: "Application of Deuteration in Drug Research", QILU PHARMACEUTICAL AFFAIRS, vol. 29, no. 11, 31 December 2010 (2010-12-31), pages 682, XP008173943
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