CHOLESTEROL-CONTAINING COMPOUNDS AND THEIR USE AS IMMUNOGENS AGAINST BORRELIA BURGDORFERI

Title:

CHOLESTEROL-CONTAINING COMPOUNDS AND THEIR USE AS IMMUNOGENS AGAINST BORRELIA BURGDORFERI

Document Type and Number:

WIPO Patent Application WO2004089969

Kind Code:

A3

Abstract:

Unique compounds that can be used for inducing an immune response to Borrelia burgdorferi in a subject by administering a therapeutically effective amount of the glycolipid to the subject. Such administration is particularly useful for preventing or treating Lyme disease in a subject. The compounds(s), and therapeutically acceptable salts thereof, may be formulated into pharmaceutical or immunogenic compositions.

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Inventors:

BEN-MENACHEM GIL (US)
KUBLER-KIELB JOANNA (US)
SCHNEERSON RACHEL (US)
ROBBINS JOHN B (US)
POZSGAY VINCE (US)

Application Number:

PCT/US2004/010007

Publication Date:

December 16, 2004

Filing Date:

April 02, 2004

Export Citation:

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Assignee:

US GOV HEALTH & HUMAN SERV (US)
BEN-MENACHEM GIL (US)
KUBLER-KIELB JOANNA (US)
SCHNEERSON RACHEL (US)
ROBBINS JOHN B (US)
POZSGAY VINCE (US)

International Classes:

C07J9/00; C07J; (IPC1-7): C07J9/00

Foreign References:

US4189471A	1980-02-19
US4229441A	1980-10-21
EP0023865A2	1981-02-11

Other References:

GIL BEN-MENACHEM ET AL.: "A newly discovered cholesteryl galactoside from Borrelia burgdorferi", PNAS, vol. 100, no. 13, 2003, pages 7913 - 7918, XP002300283
N.W.J.SCHRÖDER ET AL.: "Acylated Cholesteryl Galactoside as a Novel Immunogenic Motif in Borrelia burgdorferi Sensu Stricto", J.BIOL.CHEM., vol. 278, no. 36, 2003, pages 33645 - 33653, XP002300284

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