Title:
CHROMAN DERIVATIVE AND MEDICINAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/1995/013272
Kind Code:
A1
Abstract:
A chroman derivative represented by general formula (I), a pharmaceutically acceptable salt thereof, and a medicinal use thereof, wherein R1 is cyano, nitro, trihalomethyl, trihalomethoxy or halogen; R2 is lower alkoxyalkyl, aryloxyalkyl or dialkoxyalkyl; R3 is lower alkoxyalkyl or aryloxyalkyl; R4 is hydroxy, formyloxy or lower alkanoyloxy; X is N-H which may be substituted by lower alkyl, oxygen, sulfur or a single bond; Y is a residue of an aromatic or heterocyclic ring which may be substituted. The compound and pharmaceutically acceptable salt thereof have a prominent selective coronary vasodilator activity while having a minimized hypotensive effect. Therefore, they can selectively increase the coronary blood flow volume without the fear of causing sudden hypotension causative of tachycardia which adversely affects the heart, and hence are useful as a coronary vasodilator, in particular, as a preventive or remedy for cardiovascular disturbance such as angina pectoris or cardiac failure.
Inventors:
CHO HIDETSURA (JP)
SAYAMA SHINSUKE (JP)
KATO SUSUMU (JP)
AISAKA KAZUO (JP)
UCHIDA ITSUO (JP)
SAYAMA SHINSUKE (JP)
KATO SUSUMU (JP)
AISAKA KAZUO (JP)
UCHIDA ITSUO (JP)
Application Number:
PCT/JP1994/001901
Publication Date:
May 18, 1995
Filing Date:
November 10, 1994
Export Citation:
Assignee:
JAPAN TOBACCO INC (JP)
CHO HIDETSURA (JP)
SAYAMA SHINSUKE (JP)
KATO SUSUMU (JP)
AISAKA KAZUO (JP)
UCHIDA ITSUO (JP)
CHO HIDETSURA (JP)
SAYAMA SHINSUKE (JP)
KATO SUSUMU (JP)
AISAKA KAZUO (JP)
UCHIDA ITSUO (JP)
International Classes:
A61K31/35; A61K31/435; A61K31/44; A61K31/495; A61K31/50; A61K31/505; A61K31/535; C07D311/22; C07D311/68; C07D311/70; C07D405/04; C07D405/12; C07D487/04; C07D498/04; C08F255/00; C08F255/02; C08F255/04; C08F255/06; C08F255/08; C08F257/02; C08F279/02; C08L51/00; C08L51/06; C10M143/00; C10M149/06; C10M149/10; C10M151/02; C10M157/04; C10M167/00; C10N30/04; C10N40/25; (IPC1-7): C07D311/22; C07D311/58; C07D311/68; C07D405/04; C07D405/12; C07D498/04; C07D487/04; A61K31/35; A61K31/40; A61K31/41; A61K31/415; A61K31/435; A61K31/535
Foreign References:
| JPH0366681A | 1991-03-22 | |||
| JPH05294954A | 1993-11-09 | |||
| JPH04300880A | 1992-10-23 | |||
| JPH02300182A | 1990-12-12 | |||
| JPH03279377A | 1991-12-10 | |||
| JPH05178850A | 1993-07-20 | |||
| JPH05194496A | 1993-08-03 | |||
| JPH05294954A | 1993-11-09 | |||
| JPH04300880A | 1992-10-23 | |||
| JPH0366681A | 1991-03-22 | |||
| EP0489327A1 | 1992-06-10 | |||
| EP0415065A1 | 1991-03-06 | |||
| EP0400430A2 | 1990-12-05 |
Other References:
JOURNAL OF SYNTHETIC ORGANIC, vol. 51, no. 5, 1993, pages 412
J. AM. CHEM. SOC., vol. 113, 1991, pages 7063
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN, vol. 51, no. 5, 1993, pages 412
J. MED. CHEM, vol. 34, 1991, pages 3074
JOURNAL OF MEDICINAL CHEMISTRY, vol. 34, no. 10, 1991, pages 3074
CHEMICAL PHARMACEUTICAL BULLETIN, vol. 30, 1982, pages 832
CHEMICAL PHARMACEUTICAL BULLETIN, vol. 10, 1962, pages 580
See also references of EP 0677519A4
J. AM. CHEM. SOC., vol. 113, 1991, pages 7063
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN, vol. 51, no. 5, 1993, pages 412
J. MED. CHEM, vol. 34, 1991, pages 3074
JOURNAL OF MEDICINAL CHEMISTRY, vol. 34, no. 10, 1991, pages 3074
CHEMICAL PHARMACEUTICAL BULLETIN, vol. 30, 1982, pages 832
CHEMICAL PHARMACEUTICAL BULLETIN, vol. 10, 1962, pages 580
See also references of EP 0677519A4
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