Title:
CHROMONE DERIVATIVE AND COMPOSITION FOR DIAGNOSIS OF AMYLOID-RELATED DISEASE
Document Type and Number:
WIPO Patent Application WO/2019/168170
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a compound having high binding specificity for amyloid proteins and high blood-brain barrier permeability, and featuring rapid elimination from normal tissues. The present invention relates to: a radionuclide-labeled compound represented by formula (I) (the symbols in the formula are as defined in the description) or a pharmaceutically acceptable salt thereof; and a composition for the diagnosis of amyloid-related disease comprising the same.
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Inventors:
FUCHIGAMI TAKESHI (JP)
NAKAYAMA MORIO (JP)
YOSHIDA SAKURA (JP)
KATAYAMA FUMIHIRO (JP)
NAKAIE MARI (JP)
NAKAYAMA MORIO (JP)
YOSHIDA SAKURA (JP)
KATAYAMA FUMIHIRO (JP)
NAKAIE MARI (JP)
Application Number:
PCT/JP2019/008168
Publication Date:
September 06, 2019
Filing Date:
March 01, 2019
Export Citation:
Assignee:
UNIV NAGASAKI (JP)
International Classes:
C07D407/04; A61K51/04; A61P25/00; C07D413/04
Domestic Patent References:
| WO2013142236A1 | 2013-09-26 | |||
| WO2006057323A1 | 2006-06-01 | |||
| WO2009102498A1 | 2009-08-20 |
Foreign References:
| CN1155590C | 2004-06-30 |
Other References:
BANERJI, K.D. ET AL.: "Synthesis of some benzofurylchromones", JOURNAL OF THE INDIAN CHEMICAL SOCIETY, vol. 53, 1976, pages 1119 - 1121, ISSN: 0019-4522
BANERJI, K. D. ET AL.: "Bromination of 2-hydroxyacetophenones and preparation of some benzofurylchromones", JOURNAL OF THE INDIAN CHEMICAL SOCIETY, vol. 56, 1979, pages 62 - 65, ISSN: 0019-4522
CHARVIN, D. ET AL.: "Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, 2017, pages 8515 - 8537
CAUJOLLE,R. ET AL.: "Synthesis of 2-arylbenzothiazoles and research of antiparasitic properties", ANNALES PHARMACEUTIQUES FRANCAISES, vol. 47, 1989, pages 68 - 73, XP008166510, ISSN: 0003-4509
REDDY, K. R. ET AL.: "Synthesis of 2-carbomethoxy- and 2-(2-benzimidazolyl)chromones", JOURNAL OF THE INDIAN CHEMICAL SOCIETY, vol. 63, 1986, pages 600 - 602, ISSN: 0019-4522
MAHAJAN, P.S. ET AL.: "Synthesis and Antitubercular Activity of New Benzo[b]thiophenes", ACS MEDICINAL CHEMISTRY LETTERS, vol. 7, 2016, pages 751 - 756
GRISHKO,L. ET AL.: "Synthesis and structure investigation of benzofuran analogs of chalcone, flavone, and isoflavone", ACTA CHIMICA HUNGARICA, vol. 112, 1983, pages 401 - 410, ISSN: 0231-3146
HE,X. ET AL.: "Syntheses of 2- or 6-substituted chromones and chromone ring-opening reaction in polyphosphoric acid", CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, vol. 20, no. 11, 2004, pages 299 - 304, ISSN: 1005-9040
DATABASE Database REGISTRY [online] 2008, retrieved from STN Database accession no. 1027921-79-4
BANERJI, K. D. ET AL.: "Bromination of 2-hydroxyacetophenones and preparation of some benzofurylchromones", JOURNAL OF THE INDIAN CHEMICAL SOCIETY, vol. 56, 1979, pages 62 - 65, ISSN: 0019-4522
CHARVIN, D. ET AL.: "Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, 2017, pages 8515 - 8537
CAUJOLLE,R. ET AL.: "Synthesis of 2-arylbenzothiazoles and research of antiparasitic properties", ANNALES PHARMACEUTIQUES FRANCAISES, vol. 47, 1989, pages 68 - 73, XP008166510, ISSN: 0003-4509
REDDY, K. R. ET AL.: "Synthesis of 2-carbomethoxy- and 2-(2-benzimidazolyl)chromones", JOURNAL OF THE INDIAN CHEMICAL SOCIETY, vol. 63, 1986, pages 600 - 602, ISSN: 0019-4522
MAHAJAN, P.S. ET AL.: "Synthesis and Antitubercular Activity of New Benzo[b]thiophenes", ACS MEDICINAL CHEMISTRY LETTERS, vol. 7, 2016, pages 751 - 756
GRISHKO,L. ET AL.: "Synthesis and structure investigation of benzofuran analogs of chalcone, flavone, and isoflavone", ACTA CHIMICA HUNGARICA, vol. 112, 1983, pages 401 - 410, ISSN: 0231-3146
HE,X. ET AL.: "Syntheses of 2- or 6-substituted chromones and chromone ring-opening reaction in polyphosphoric acid", CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, vol. 20, no. 11, 2004, pages 299 - 304, ISSN: 1005-9040
DATABASE Database REGISTRY [online] 2008, retrieved from STN Database accession no. 1027921-79-4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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