Title:
CHROMONE DERIVATIVE HAVING LINEAR SIDE CHAIN
Document Type and Number:
WIPO Patent Application WO/2014/030688
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a compound having bone formation promoting activity. The solution is a compound having general formula (I) or a pharmaceutically acceptable salt thereof. [In the formula, R1 is a methyl group, etc., R2 is a hydroxyl group, etc., R3 is a hydrogen atom, etc., R4 is a methyl group, etc., and A is a hydrogen atom, etc.]
Inventors:
KAWAKAMI KATSUHIRO (JP)
KIHO TOSHIHIRO (JP)
TENGEIJI ATSUSHI (JP)
AOKI KAZUMASA (JP)
YANO KAZUKI (JP)
KIHO TOSHIHIRO (JP)
TENGEIJI ATSUSHI (JP)
AOKI KAZUMASA (JP)
YANO KAZUKI (JP)
Application Number:
PCT/JP2013/072353
Publication Date:
February 27, 2014
Filing Date:
August 22, 2013
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
C07D311/22; A61K31/352; A61K31/41; A61K31/4178; A61K31/5377; A61K31/695; A61P19/00; A61P19/08; A61P19/10; A61P43/00; C07D311/24; C07D311/56; C07D311/58; C07D405/06; C07F7/18
Domestic Patent References:
| WO2009101959A1 | 2009-08-20 |
Foreign References:
| CN102442985A | 2012-05-09 | |||
| JP2005501041A | 2005-01-13 | |||
| JP2004537556A | 2004-12-16 | |||
| JPH04502322A | 1992-04-23 | |||
| JPS56158777A | 1981-12-07 | |||
| GB1292601A | 1972-10-11 | |||
| JPS4833750B1 | 1973-10-16 |
Other References:
CHEN Y. ET AL.: "Antitumor agents 292. Design, synthesis and pharmacological study of S- and O-substituted 7-mercapto- or hydroxy-coumarins and chromones as potent cytotoxic agents", EUR J MED CHEM., vol. 49, 2012, pages 74 - 85
CHEN Y. ET AL.: "Anti-AIDS agents 86. Synthesis and anti-HIV evaluation of 2',3'-seco-3'-nor DCP and DCK analogues", EUR J MED CHEM., vol. 46, 2011, pages 4924 - 4936
MEWSHAW R.E. ET AL.: "New generation dopaminergic agents. Part 8: heterocyclic bioisosteres that exploit the 7-OH-2- (aminomethyl)chroman D2 template", BIOORG MED CHEM LETT., vol. 12, 2002, pages 271 - 274
MORRIS J. ET AL.: "A novel synthesis of 2-aminochromones via phosgeniminium salts", J ORG CHEM., vol. 57, 1992, pages 6502 - 6508
COHEN N. ET AL.: "3,4-Dihydro-2H-1-benzopyran- 2-carboxylic acids and related compounds as leukotriene antagonists", J MED CHEM., vol. 32, 1989, pages 1842 - 1860
CAIRNS H. ET AL.: "Synthesis and structure- activity relationships of disodium cromoglycate and some related compounds", J MED CHEM., vol. 15, 1972, pages 583 - 589
ELLIS G. P. ET AL.: "Benzopyrones. Part 22. Synthesis of new 4-oxochromene polycarboxylic acids", J CHEM RES (S)., 1985, pages 372 - 373
BARKER G. ET AL.: "Benzopyrones. Part II. 7-hydroxy-4-oxochromen-2-carboxylic acid and some of its derivatives", J CHEM SOC (C)., 1970, pages 2609 - 2612
FITTON A.O. ET AL.: "Pharmacologically active 4-oxo-4H-chromen-2-carboxylic acids. Part II. The synthesis of 4-oxo-4H-chromen-2-carboxylic acids containing a fused imidazole or oxazole ring", J CHEM SOC (C)., 1970, pages 2518 - 2522
MING C. ET AL.: "Bromination of 7-O-substituted- 8-methyl-coumarins and 4H-chromen-4-ones with N-bromosuccinimide in CC14", CHINESE J ORG CHEM., vol. 30, 2010, pages 1737 - 1741
PATONAY T. ET AL.: "Synthesis of novel [(5H- tetrazolyl)alkoxy]-substituted chromone and chromanone derivatives", BULL SOC CHIM FR., vol. 134, 1997, pages 653 - 667
GLOZMAN S.H. ET AL.: "Synthesis and pharmacological study of 7-hydroxy- and 7-methoxy-8-dialkylaminomethylchromone-2- carboxylic acid esters", KHIMIKO- FARMATSEVTICHESKII ZHURNAL, vol. 8, 1974, pages 11 - 14
CHEN Y. ET AL.: "Anti-AIDS agents 86. Synthesis and anti-HIV evaluation of 2',3'-seco-3'-nor DCP and DCK analogues", EUR J MED CHEM., vol. 46, 2011, pages 4924 - 4936
MEWSHAW R.E. ET AL.: "New generation dopaminergic agents. Part 8: heterocyclic bioisosteres that exploit the 7-OH-2- (aminomethyl)chroman D2 template", BIOORG MED CHEM LETT., vol. 12, 2002, pages 271 - 274
MORRIS J. ET AL.: "A novel synthesis of 2-aminochromones via phosgeniminium salts", J ORG CHEM., vol. 57, 1992, pages 6502 - 6508
COHEN N. ET AL.: "3,4-Dihydro-2H-1-benzopyran- 2-carboxylic acids and related compounds as leukotriene antagonists", J MED CHEM., vol. 32, 1989, pages 1842 - 1860
CAIRNS H. ET AL.: "Synthesis and structure- activity relationships of disodium cromoglycate and some related compounds", J MED CHEM., vol. 15, 1972, pages 583 - 589
ELLIS G. P. ET AL.: "Benzopyrones. Part 22. Synthesis of new 4-oxochromene polycarboxylic acids", J CHEM RES (S)., 1985, pages 372 - 373
BARKER G. ET AL.: "Benzopyrones. Part II. 7-hydroxy-4-oxochromen-2-carboxylic acid and some of its derivatives", J CHEM SOC (C)., 1970, pages 2609 - 2612
FITTON A.O. ET AL.: "Pharmacologically active 4-oxo-4H-chromen-2-carboxylic acids. Part II. The synthesis of 4-oxo-4H-chromen-2-carboxylic acids containing a fused imidazole or oxazole ring", J CHEM SOC (C)., 1970, pages 2518 - 2522
MING C. ET AL.: "Bromination of 7-O-substituted- 8-methyl-coumarins and 4H-chromen-4-ones with N-bromosuccinimide in CC14", CHINESE J ORG CHEM., vol. 30, 2010, pages 1737 - 1741
PATONAY T. ET AL.: "Synthesis of novel [(5H- tetrazolyl)alkoxy]-substituted chromone and chromanone derivatives", BULL SOC CHIM FR., vol. 134, 1997, pages 653 - 667
GLOZMAN S.H. ET AL.: "Synthesis and pharmacological study of 7-hydroxy- and 7-methoxy-8-dialkylaminomethylchromone-2- carboxylic acid esters", KHIMIKO- FARMATSEVTICHESKII ZHURNAL, vol. 8, 1974, pages 11 - 14
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
Kimiki Ishibashi (JP)
Kimiki Ishibashi (JP)
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