Title:
REMEDIES/PREVENTIVES FOR CHRONIC SKIN DISEASE
Document Type and Number:
WIPO Patent Application WO/2006/041121
Kind Code:
A1
Abstract:
It is intended to provide: a remedy and/or a preventive for a chronic skin disease which comprises, as the active ingredients, (a) a phosphodiesterase (PDE)-IV inhibitor or a pharmacologically acceptable salt thereof and (b) a steroid drug; a remedy and/or a preventive for a chronic skin disease for administering the following active ingredients, either simultaneously or separately at an interval, (a) a PDE-IV inhibitor or a pharmacologically acceptable salt thereof and (b) a steroid drug; a kit for treating and/or preventing a chronic skin disease characterized by comprising (a) a first component containing a PDE-IV inhibitor or a pharmacologically acceptable salt thereof and (b) a second component containing a steroid drug, and so on.
Inventors:
HARADA DAISUKE
KOBAYASHI KATSUYA
MANABE HARUHIKO
OHSHIMA ETSUO
KOBAYASHI KATSUYA
MANABE HARUHIKO
OHSHIMA ETSUO
Application Number:
PCT/JP2005/018855
Publication Date:
April 20, 2006
Filing Date:
October 13, 2005
Export Citation:
Assignee:
KYOWA HAKKO KOGYO KK (JP)
HARADA DAISUKE
KOBAYASHI KATSUYA
MANABE HARUHIKO
OHSHIMA ETSUO
HARADA DAISUKE
KOBAYASHI KATSUYA
MANABE HARUHIKO
OHSHIMA ETSUO
International Classes:
A61K45/06; A61K31/277; A61K31/357; A61K31/4409; A61K31/4427; A61K31/443; A61K31/4433; A61K31/496; A61K31/573; A61K31/58; A61P17/00; A61P17/04; A61P17/06; A61P29/00; A61P37/08; A61P43/00; C07D213/30; C07D213/75; C07D405/06; C07D405/12; C07J5/00; C07J7/00; C07J71/00
Domestic Patent References:
| WO2001019373A2 | 2001-03-22 | |||
| WO2004058729A1 | 2004-07-15 | |||
| WO1996036624A1 | 1996-11-21 | |||
| WO1999016768A1 | 1999-04-08 | |||
| WO2000014085A1 | 2000-03-16 | |||
| WO2005049581A1 | 2005-06-02 |
Foreign References:
| JP2002504091A | 2002-02-05 | |||
| JPH08512041A | 1996-12-17 | |||
| JPH07504442A | 1995-05-18 | |||
| JP2002513017A | 2002-05-08 | |||
| JPH06507405A | 1994-08-25 | |||
| JP2003513028A | 2003-04-08 |
Other References:
ASHTON MJ ET AL: "Selective Type IV Phosphodiesterase Inhibitors as Antiasthmatic Agents. The Syntheses and Biological Activities of 3-(Cyclopentyloxy)-4-methoxybenzamides and Analogues.", J MED CHEM., vol. 37, 1994, pages 1696 - 1703, XP002015726
CHRISTENSEN SB ET AL: "1,4-Cyclohexanecarboxylates: Potent and Selective Inhibitors of Phosophodiesterase 4 for the Treatment of Asthma.", J MED CHEM., vol. 41, 1998, pages 821 - 835, XP002173934
DUPLANTIER AJ ET AL: "7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as Novel Inhibitors of Human Eosinophil Phosphodiesterase.", J MED CHEM., vol. 41, 1998, pages 2268 - 2277, XP002938447
BAUMER W ET AL: "AWD 12-281, a highly selective phosphodiesterase 4 inhibitor, is effective in the prevention and treatment of inflammatory reactions in a model of allergic dermatitis.", J PHARM PHARMACOL., vol. 55, 2003, pages 1107 - 1114, XP009019412
BAUMER W ET AL: "Effects of the phosphodiesterase 4 inhibitors SB 207499 and AWD 12-281 on the inflammatory reaction in a model of allergic dermatitis.", EUR J PHARMACOL., vol. 446, 2002, pages 195 - 200, XP002258973
GRIFFITHS C E M ET AL: "Randomized comparison of the type 4 phosphodiesterase inhibitor cipamfylline cream, cream vehicle and hydrocortisone 17-butyrate cream for the treatment of atopic dermatitis.", BR J DERMATOL., vol. 147, 2002, pages 299 - 307, XP002994971
HANIFIN JM ET AL: "Biochemical and immunologic mechanisms in atopic dermatitis: New targets for emerging therapies.", J AM ACAD DERMATOL., vol. 41, 1999, pages 72 - 77, XP008008916
DOHERTY AM ET AL: "Phosphodiesterase 4 inhibitors as novel anti-inflammatory agents.", CURR OPIN CHEM BIOL., vol. 3, 1999, pages 466 - 473, XP002994972
GRISWOLD D E ET AL: "SB 207499 (Ariflo), a Second Generation Phosphodiesterase 4 Inhibitor, Reduces Tumor Necrosis Factor Alpha and Interleukin-4 Production in Vivo.", J PHARMACOL EXP THER., vol. 287, no. 2, 1998, pages 705 - 711, XP001121243
CHRISTENSEN SB ET AL: "1,4-Cyclohexanecarboxylates: Potent and Selective Inhibitors of Phosophodiesterase 4 for the Treatment of Asthma.", J MED CHEM., vol. 41, 1998, pages 821 - 835, XP002173934
DUPLANTIER AJ ET AL: "7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as Novel Inhibitors of Human Eosinophil Phosphodiesterase.", J MED CHEM., vol. 41, 1998, pages 2268 - 2277, XP002938447
BAUMER W ET AL: "AWD 12-281, a highly selective phosphodiesterase 4 inhibitor, is effective in the prevention and treatment of inflammatory reactions in a model of allergic dermatitis.", J PHARM PHARMACOL., vol. 55, 2003, pages 1107 - 1114, XP009019412
BAUMER W ET AL: "Effects of the phosphodiesterase 4 inhibitors SB 207499 and AWD 12-281 on the inflammatory reaction in a model of allergic dermatitis.", EUR J PHARMACOL., vol. 446, 2002, pages 195 - 200, XP002258973
GRIFFITHS C E M ET AL: "Randomized comparison of the type 4 phosphodiesterase inhibitor cipamfylline cream, cream vehicle and hydrocortisone 17-butyrate cream for the treatment of atopic dermatitis.", BR J DERMATOL., vol. 147, 2002, pages 299 - 307, XP002994971
HANIFIN JM ET AL: "Biochemical and immunologic mechanisms in atopic dermatitis: New targets for emerging therapies.", J AM ACAD DERMATOL., vol. 41, 1999, pages 72 - 77, XP008008916
DOHERTY AM ET AL: "Phosphodiesterase 4 inhibitors as novel anti-inflammatory agents.", CURR OPIN CHEM BIOL., vol. 3, 1999, pages 466 - 473, XP002994972
GRISWOLD D E ET AL: "SB 207499 (Ariflo), a Second Generation Phosphodiesterase 4 Inhibitor, Reduces Tumor Necrosis Factor Alpha and Interleukin-4 Production in Vivo.", J PHARMACOL EXP THER., vol. 287, no. 2, 1998, pages 705 - 711, XP001121243
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