Title:
CHRYSIN DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/001268
Kind Code:
A1
Abstract:
The present invention relates to the technical field of drugs, and specifically relates to a chrysin derivative, and a preparation method therefor and the use thereof. The chrysin derivative has a structure as represented by formula I, and the biological activity and bioavailability thereof are significantly higher than those of chrysin. The chrysin derivative can prevent and/or treat diseases, such as hyperglycemia, hyperlipidemia, Alzheimer's disease, senile dementia, Parkinson's disease, amyotrophic lateral sclerosis, cerebral ischemia, brain injury, obesity, diabetes and/or diabetic complications, diabetic eye diseases, diabetic nephropathy, dyslipidemia, atherosclerosis, fatty liver, non-alcoholic fatty liver, cirrhosis, hepatitis, obstructive jaundice and myocardial infarction.
Inventors:
YANG XIFEI (CN)
XIE YONGMEI (CN)
LI SHUPENG (CN)
YANG CHAO (CN)
LIU GONGPING (CN)
ZHANG RUIMING (CN)
YE TAO (CN)
XIE YONGMEI (CN)
LI SHUPENG (CN)
YANG CHAO (CN)
LIU GONGPING (CN)
ZHANG RUIMING (CN)
YE TAO (CN)
Application Number:
PCT/CN2022/107271
Publication Date:
January 26, 2023
Filing Date:
July 22, 2022
Export Citation:
Assignee:
SHENZHEN FENGYU BIOMEDICAL TECH CO LTD (CN)
SHAANXI HONGDE AGRICULTURE AND FORESTRY TECH CO LTD (CN)
SHANGLUO WEIAN IND CO LTD (CN)
SHAANXI HONGDE AGRICULTURE AND FORESTRY TECH CO LTD (CN)
SHANGLUO WEIAN IND CO LTD (CN)
International Classes:
C07D311/30; A61K31/352; A61K31/453; A61K31/496; A61K31/5377; A61P1/16; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P13/12; A61P21/00; A61P25/00; A61P25/16; A61P25/28; A61P27/02; A61P29/00; C07D405/12
Foreign References:
| CN108299367A | 2018-07-20 | |||
| CN104387358A | 2015-03-04 | |||
| CN104860993A | 2015-08-26 | |||
| KR20150101436A | 2015-09-03 | |||
| US4202825A | 1980-05-13 | |||
| CN113773293A | 2021-12-10 | |||
| CN113768915A | 2021-12-10 | |||
| CN108586411A | 2018-09-28 | |||
| CN103059005A | 2013-04-24 |
Other References:
DATABASE REGISTRY ANONYMOUS : "-Carbamic acid, N,N-dimethyl-, 5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7- yl ester (CA INDEX NAME) ", XP093026647, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "-Carbamic acid, N,N-dimethyl-, 5-methoxy-4-oxo-2-phenyl-4H-1-benzopyran-7- yl ester (CA INDEX NAME)", XP093026648, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "-Carbamic acid, N,N-dimethyl-, 5-ethoxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl ester (CA INDEX NAME) ", XP093026650, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "-Carbamic acid, N,N-dimethyl-, 5-methoxy-4-oxo-2-phenyl-4H-1-benzopyran-7- yl ester (CA INDEX NAME)", XP093026648, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "-Carbamic acid, N,N-dimethyl-, 5-ethoxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl ester (CA INDEX NAME) ", XP093026650, retrieved from STN
Attorney, Agent or Firm:
BEIJING GAOWO LAW FIRM (CN)
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