Title:
CHYMASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO/1999/032459
Kind Code:
A1
Abstract:
Heterocyclic amide compounds represented by general formula (I), or pharmacologically acceptable salts thereof; drug compositions containing the same; and use thereof as drugs (wherein each symbol is as defined in the description). The compounds exhibit an excellent chymase-inhibiting activity for mammals including $i(Homo sapiens), and are therefore useful as orally or parenterally administrable chymase inhibitors and thus effective in preventing or treating various diseases caused by angiotensin II or other diseases caused by chymase.
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Inventors:
YOSHIMURA TAKUYA (JP)
AKAHOSHI FUMIHIKO (JP)
EDA MASAHIRO (JP)
SAKASHITA HIROSHI (JP)
ASHIMORI ATSUYUKI (JP)
FUKUYAMA HAJIME (JP)
NAKAJIMA MASAHIDE (JP)
OOTSUKA TATSUYUKI (JP)
TANAKA MIKIO (JP)
IMADA TERUAKI (JP)
AKAHOSHI FUMIHIKO (JP)
EDA MASAHIRO (JP)
SAKASHITA HIROSHI (JP)
ASHIMORI ATSUYUKI (JP)
FUKUYAMA HAJIME (JP)
NAKAJIMA MASAHIDE (JP)
OOTSUKA TATSUYUKI (JP)
TANAKA MIKIO (JP)
IMADA TERUAKI (JP)
Application Number:
PCT/JP1998/005786
Publication Date:
July 01, 1999
Filing Date:
December 21, 1998
Export Citation:
Assignee:
YOSHITOMI PHARMACEUTICAL (JP)
YOSHIMURA TAKUYA (JP)
AKAHOSHI FUMIHIKO (JP)
EDA MASAHIRO (JP)
SAKASHITA HIROSHI (JP)
ASHIMORI ATSUYUKI (JP)
FUKUYAMA HAJIME (JP)
NAKAJIMA MASAHIDE (JP)
OTSUKA TATSUYUKI (JP)
TANAKA MIKIO (JP)
IMADA TERUAKI (JP)
YOSHIMURA TAKUYA (JP)
AKAHOSHI FUMIHIKO (JP)
EDA MASAHIRO (JP)
SAKASHITA HIROSHI (JP)
ASHIMORI ATSUYUKI (JP)
FUKUYAMA HAJIME (JP)
NAKAJIMA MASAHIDE (JP)
OTSUKA TATSUYUKI (JP)
TANAKA MIKIO (JP)
IMADA TERUAKI (JP)
International Classes:
C07D239/46; C07D401/04; C07D401/12; C07K14/81; (IPC1-7): C07D239/47; A61K31/44; A61K31/505; A61K31/535; A61K31/55; C07D213/72; C07D401/04
Domestic Patent References:
| WO1996033974A1 | 1996-10-31 |
Foreign References:
| JPH107661A | 1998-01-13 |
Attorney, Agent or Firm:
Takashima, Hajime (Hiranomachi 3-chome Chuo-ku Osaka-shi Osaka, JP)
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