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Title:
CINNAMOYL DERIVATIVES AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2005/028441
Kind Code:
A1
Abstract:
Cinnamoyl derivatives represented by the general formula (I) which have inhibitory effects on type I collagen gene transcription: (I) wherein A is a benzene ring or a pyridine ring; Y&agr is a group on carbon which is selected from group X0 or group Y0, with the proviso that two adjacent Y&agr ’s may form a group selected from group Z0 and fused with the ring A; q is an integer of 0 to 5; group X0 includes OH and so on; group Y0 includes 3- to 12-membered carbo- and hetero-cycles which may be substituted with OH or the like; group Z0 includes 5- to 12-membered carbo- and hetero-cycles fused with the ring A which cycles may be substituted with thio or the like; Q&agr is optionally substituted hydroxy or amino; W&agr is O or -NT&agr - (wherein T&agr is H or a substituent); and K&agr and L&agr are each H or a substituent, or K&agr and L&agr may form optionally substituted, C1-10 alkylene or alkenylene, with the proviso that the compound wherein A is a benzene ring, W&agr is O, K&agr and L&agr form 1,3-butadienylene, Q&agr is OH, q is 1, and Y&agr is OEt is excluded.

Inventors:
TOMIGAHARA YOSHITAKA (JP)
HIGASHI KIYOSHI (JP)
TAKAHASHI JUNYA (JP)
Application Number:
PCT/JP2004/013989
Publication Date:
March 31, 2005
Filing Date:
September 16, 2004
Export Citation:
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Assignee:
SUMITOMO CHEMICAL CO (JP)
TOMIGAHARA YOSHITAKA (JP)
HIGASHI KIYOSHI (JP)
TAKAHASHI JUNYA (JP)
International Classes:
A61K8/49; A61K31/366; A61K31/37; A61K31/4412; A61K31/4439; A61K31/4704; A61K31/5377; A61P1/16; A61P9/10; A61P9/12; A61P11/00; A61P13/12; A61P17/02; A61P17/14; A61P43/00; A61Q7/00; C07D311/56; (IPC1-7): C07D213/69; A61K7/06; A61K31/366; A61K31/37; A61K31/4412; A61K31/4439; A61K31/4704; A61K31/5377; A61P1/16; A61P9/10; A61P9/12; A61P11/00; A61P13/12; A61P17/02; A61P17/14; A61P43/00; C07D215/22; C07D309/38; C07D311/56; C07D407/10; C07D413/10
Domestic Patent References:
WO2001079187A22001-10-25
WO1997035565A11997-10-02
WO2003080592A12003-10-02
Foreign References:
JP2001089412A2001-04-03
JP2002371078A2002-12-26
JP2001504080A2001-03-27
JP2002541253A2002-12-03
JPS411412B11966-02-03
JPS5046666A1975-04-25
US4017633A1977-04-12
JPH03503635A1991-08-15
JPH09227547A1997-09-02
JP2004123621A2004-04-22
JP2004123620A2004-04-22
Other References:
RACHEDI Y. ET AL.: "Synthesis of 4-hydroxy-6-methyl-3-beta-arylpropionyl-2-pyrones by selective catalytic hydrogenation of 3-cinnamoyl-4-hydroxy-6-methyl-2-pyrones", SYNTHETIC COMMUNICATIONS, vol. 19, no. 20, 1989, pages 3437 - 3442, XP002969588
UKITA CH. ET AL.: "In vitro screening of tricarbonylmethane and related compounds for theri antitumor effects by cylinder agar plate method", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 8, 1961, pages 1016 - 1020, XP002904572
KALECHITS G.V. ET AL.: "Synthesis and properties of 3-cinnamoyl-4-hydroxy-2-quinolone", RUSSIAN JOURNAL OF CENERAL CHEMISTRY (TRANSALTION OF ZHURNAL OBSHCHEI KHIMII), vol. 71, no. 8, 2001, pages 1275 - 1260, XP002904573
See also references of EP 1671950A4
J. INVEST. DERMATOL., vol. 94, 1990, pages 365
PROC.NATL.ACAD.SCI.USA, vol. 88, 1991, pages 6642
Attorney, Agent or Firm:
Enomoto, Masayuki c/o Sumitomo Chemical Intellectual Property Service (Limited 5-33, Kitahama 4-chome, Chuo-k, Osaka-shi Osaka 50, JP)
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