Title:
CIRCIKBKB INHIBITOR AND USE OF CIRCLKBKB DETECTION REAGENT IN DIAGNOSIS, TREATMENT AND PROGNOSIS KIT FOR BREAST CANCER BONE METASTASIS
Document Type and Number:
WIPO Patent Application WO/2023/000282
Kind Code:
A1
Abstract:
The present invention belongs to the technical fields of biotechnology and medicine, and specifically relates to a circIKBKB inhibitor and the use of a circIKBKB detection reagent in a diagnosis, treatment and prognosis kit for breast cancer bone metastasis. The kit comprises one of RT-PCR, Q-PCR, Northern blot, FISH or ISH kits, and comprises primers as shown in SEQ ID NOs: 1-2 of the sequence list for a linker sequence of circIKBKB or a probe as shown in SEQ ID NO: 3 of the sequence list. The present invention also relates to an antisense oligonucleotide targeting a linker sequence of circIKBKB. The antisense oligonucleotide is used as a reagent for inhibiting the generation of circIKBKB and is used for preparing a drug for treating breast cancer bone metastasis; and the eIF4A3-IN-2 inhibitor is used for preparing a drug for treating breast cancer bone metastasis.
Inventors:
LI JUN (CN)
SONG LIBING (CN)
XU YINGRU (CN)
ZHANG SHUXIA (CN)
WU XINGUI (CN)
LIAO XINYI (CN)
LI MAN (CN)
CHEN SUWEN (CN)
LI XINCHENG (CN)
SONG LIBING (CN)
XU YINGRU (CN)
ZHANG SHUXIA (CN)
WU XINGUI (CN)
LIAO XINYI (CN)
LI MAN (CN)
CHEN SUWEN (CN)
LI XINCHENG (CN)
Application Number:
PCT/CN2021/108014
Publication Date:
January 26, 2023
Filing Date:
July 23, 2021
Export Citation:
Assignee:
SUN YAT SEN UNIV CANCER CENTER (CN)
UNIV SUN YAT SEN (CN)
UNIV SUN YAT SEN (CN)
International Classes:
C12Q1/6886; A61K45/00; A61P35/00; C12N15/113
Domestic Patent References:
| WO2016178236A1 | 2016-11-10 | |||
| WO2015052583A2 | 2015-04-16 |
Foreign References:
| CN102559887A | 2012-07-11 | |||
| CN105980576A | 2016-09-28 | |||
| CN113025718A | 2021-06-25 |
Other References:
3 March 2015 (2015-03-03), ANONYMOUS: "hsa_circ_0084100", XP009543218
PARK BAE KEUN; ZHANG HONGLAI; ZENG QINGHUA; DAI JINLU; KELLER EVAN T; GIORDANO THOMAS; GU KENI; SHAH VEENA; PEI LEI; ZARBO RICHARD: "NF-kappa B in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF", NATURE MEDICINE, NATURE PUBLISHING GROUP US, NEW YORK, vol. 13, no. 1, 1 January 2007 (2007-01-01), New York, pages 62 - 69, XP009117859, ISSN: 1078-8956, DOI: 10.1038/nm1519
ZHU YUANHANG, REN CHENCHEN, YANG LI: "Effect of eukaryotic translation initiation factor 4A3 in malignant tumors (Review)", ONCOLOGY LETTERS, SPANDIDOS PUBLICATIONS, GR, vol. 21, no. 5, GR , XP093027253, ISSN: 1792-1074, DOI: 10.3892/ol.2021.12619
ZHENG XIAYING, HUANG MENGGE, XING LEI, YANG RUI, WANG XIAOSONG, JIANG RONG, ZHANG LUYU, CHEN JUNXIA: "The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer", MOLECULAR CANCER, vol. 19, no. 1, 1 December 2020 (2020-12-01), XP093027256, DOI: 10.1186/s12943-020-01183-9
ZHONG SHAN-LIANG, JI-FENG FENG: "Research Progress on Relationship of Circular RNAs with Development，Progression and Drug-resistance of Breast Cancer", JOURNAL OF CHINESE ONCOLOGY, vol. 26, no. 12, 20 December 2020 (2020-12-20), pages 1013 - 1018, XP093027272, DOI: 10.11735/j.issn.1671-170X.2020.12.B001
PARK BAE KEUN; ZHANG HONGLAI; ZENG QINGHUA; DAI JINLU; KELLER EVAN T; GIORDANO THOMAS; GU KENI; SHAH VEENA; PEI LEI; ZARBO RICHARD: "NF-kappa B in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF", NATURE MEDICINE, NATURE PUBLISHING GROUP US, NEW YORK, vol. 13, no. 1, 1 January 2007 (2007-01-01), New York, pages 62 - 69, XP009117859, ISSN: 1078-8956, DOI: 10.1038/nm1519
ZHU YUANHANG, REN CHENCHEN, YANG LI: "Effect of eukaryotic translation initiation factor 4A3 in malignant tumors (Review)", ONCOLOGY LETTERS, SPANDIDOS PUBLICATIONS, GR, vol. 21, no. 5, GR , XP093027253, ISSN: 1792-1074, DOI: 10.3892/ol.2021.12619
ZHENG XIAYING, HUANG MENGGE, XING LEI, YANG RUI, WANG XIAOSONG, JIANG RONG, ZHANG LUYU, CHEN JUNXIA: "The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer", MOLECULAR CANCER, vol. 19, no. 1, 1 December 2020 (2020-12-01), XP093027256, DOI: 10.1186/s12943-020-01183-9
ZHONG SHAN-LIANG, JI-FENG FENG: "Research Progress on Relationship of Circular RNAs with Development，Progression and Drug-resistance of Breast Cancer", JOURNAL OF CHINESE ONCOLOGY, vol. 26, no. 12, 20 December 2020 (2020-12-20), pages 1013 - 1018, XP093027272, DOI: 10.11735/j.issn.1671-170X.2020.12.B001
Attorney, Agent or Firm:
ZHUANLI IP LAW FIRM (CN)
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